Maitake Medicinal Mushroom, Grifola frondosa (Agaricomycetes), and Its Neurotrophic Properties: A Mini-Review
文献类型: 外文期刊
作者: Naguib, Adrina Mohamad 1 ; Apparoo, Yasaaswini 1 ; Xiong, Chuan 3 ; Phan, Chia Wei 1 ;
作者机构: 1.Univ Malaya, Fac Pharm, Dept Pharmaceut Life Sci, Kuala Lumpur 50603, Malaysia
2.Univ Malaya, Mushroom Res Ctr, Kuala Lumpur 50603, Malaysia
3.Sichuan Acad Agr Sci, Biotechnol & Nucl Technol Res Inst, Chengdu 610061, Peoples R China
4.Univ Malaya Med Ctr, Clin Invest Ctr, 5th Floor,East Tower, Kuala Lumpur 59100, Malaysia
关键词: Grifola frondosa; neurodegeneration; antioxidative; anti-inflammatory; anti-beta-amyloid; tau protein; medicinal mushrooms
期刊名称:INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS ( 影响因子:1.2; 五年影响因子:1.4 )
ISSN: 1521-9437
年卷期: 2023 年 25 卷 2 期
页码:
收录情况: SCI
摘要: Neurodegeneration is one of the most common manifestations in an aging population. The occurrence of oxidative stress and neuroinflammation are the main contributors to the phenomenon. Neurologic conditions such as Alzheimer's disease (AD) and Parkinson's disease (PD) are challenging to treat due to their irreversible manner as well as the lack of effective treatment. Grifola frondosa (Dicks.: Fr.) S.F. Gray, or maitake mushroom, is believed to be a potential choice as a therapeutic agent for neurodegenerative diseases. G. frondosa is known to be a functional food that has a wide variety of medicinal purposes. Thus, this review emphasizes the neuroprotective effects and the chemical composition of G. frondosa. Various studies have described that G. frondosa can protect and proliferate neuronal cells through neurogenesis, antioxidative, anti-inflammatory, and anti-beta-amyloid activities. The mechanism of action behind these therapeutic findings in various in vitro and in vivo models has also been intensively studied. In this mini review, we also summarized the chemical composition of G. frondosa to provide a better understanding of the presence of nutritional compounds in G. frondosa.
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