MAK: a machine learning framework improved genomic prediction via multi-target ensemble regressor chains and automatic selection of assistant traits

文献类型： 外文期刊

第一作者： Liang, Mang

作者： Liang, Mang;Cao, Sheng;Deng, Tianyu;Du, Lili;Li, Keanning;An, Bingxing;Du, Yueying;Xu, Lingyang;Zhang, Lupei;Gao, Xue;Li, Junya;Gao, Huijiang;Guo, Peng;Gao, Huijiang

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关键词： multi-target regression; ensemble regressor chains; genomic prediction; multi-trait; machine learning

期刊名称：BRIEFINGS IN BIOINFORMATICS （ 影响因子：9.5； 五年影响因子：10.6 ）

ISSN： 1467-5463

年卷期： 2023 年 24 卷 2 期

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收录情况： SCI

摘要： Incorporating the genotypic and phenotypic of the correlated traits into the multi-trait model can significantly improve the prediction accuracy of the target trait in animal and plant breeding, as well as human genetics. However, in most cases, the phenotypic information of the correlated and target trait of the individual to be evaluated was null simultaneously, particularly for the newborn. Therefore, we propose a machine learning framework, MAK, to improve the prediction accuracy of the target trait by constructing the multi-target ensemble regression chains and selecting the assistant trait automatically, which predicted the genomic estimated breeding values of the target trait using genotypic information only. The prediction ability of MAK was significantly more robust than the genomic best linear unbiased prediction, BayesB, BayesRR and the multi trait Bayesian method in the four real animal and plant datasets, and the computational efficiency of MAK was roughly 100 times faster than BayesB and BayesRR.

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