Incorporating genome-wide and transcriptome-wide association studies to identify genetic elements of longissimus dorsi muscle in Huaxi cattle
文献类型: 外文期刊
第一作者: Liang, Mang
作者: Liang, Mang;An, Bingxing;Deng, Tianyu;Du, Lili;Li, Keanning;Cao, Sheng;Du, Yueying;Xu, Lingyang;Zhang, Lupei;Gao, Xue;Li, Junya;Gao, Huijiang;Cao, Yang;Zhao, Yuming
作者机构:
关键词: longissimus dorsi muscle; GWAS; TWAS; FCT; Huaxi cattle
期刊名称:FRONTIERS IN GENETICS ( 影响因子:3.7; 五年影响因子:4.3 )
ISSN:
年卷期: 2023 年 13 卷
页码:
收录情况: SCI
摘要: Locating the genetic variation of important livestock and poultry economic traits is essential for genetic improvement in breeding programs. Identifying the candidate genes for the productive ability of Huaxi cattle was one crucial element for practical breeding. Based on the genotype and phenotype data of 1,478 individuals and the RNA-seq data of 120 individuals contained in 1,478 individuals, we implemented genome-wide association studies (GWAS), transcriptome-wide association studies (TWAS), and Fisher's combined test (FCT) to identify the candidate genes for the carcass trait, the weight of longissimus dorsi muscle (LDM). The results indicated that GWAS, TWAS, and FCT identified seven candidate genes for LDM altogether: PENK was located by GWAS and FCT, PPAT was located by TWAS and FCT, and XKR4, MTMR3, FGFRL1, DHRS4, and LAP3 were only located by one of the methods. After functional analysis of these candidate genes and referring to the reported studies, we found that they were mainly functional in the progress of the development of the body and the growth of muscle cells. Combining advanced breeding techniques such as gene editing with our study will significantly accelerate the genetic improvement for the future breeding of Huaxi cattle.
分类号:
- 相关文献
作者其他论文 更多>>
-
Transcriptomic analysis reveals diverse expression patterns underlying the fiber diameter of oxidative and glycolytic skeletal muscles in steers
作者:Wang, Wenxiang;Zhang, Tianliu;Du, Lili;Li, Keanning;Zhang, Lupei;Li, Haipeng;Gao, Xue;Xu, Lingyang;Li, Junya;Gao, Huijiang;Gao, Huijiang
关键词:RNA sequencing; Cattle; Differentially expressed genes; Muscle fiber size; WGCNA
-
Proteome changes of dairy calves rumen epithelium from birth to postweaning
作者:Zheng, Kaizhi;Wu, Jianliang;Cao, Yang;Jiang, Yongqing;Huang, Xin;Jiang, Junfang;Ullah, Saif
关键词:proteome; dairy calves; rumen; epithelium; postnatal development
-
Transcriptomics and Lipid Metabolomics Analysis of Subcutaneous, Visceral, and Abdominal Adipose Tissues of Beef Cattle
作者:Du, Lili;Chang, Tianpeng;An, Bingxing;Liang, Mang;Deng, Tianyu;Li, Keanning;Cao, Sheng;Du, Yueying;Gao, Xue;Xu, Lingyang;Zhang, Lupei;Li, Junya;Gao, Huijiang;Cao, Sheng;Du, Yueying
关键词:transcriptomics; lipid metabolomics; adipose tissue; beef cattle
-
Comparative analysis of carcass traits and meat quality in indigenous Chinese cattle breeds
作者:Ge, Fei;Li, Junya;Gao, Han;Wang, Xiujuan;Zhang, Xiaobei;Gao, Huijiang;Zhang, Lupei;Xu, Lingyang;Gao, Xue;Zhu, Bo;Wang, Zezhao;Chen, Yan;Zhang, Xiaobei;Chen, Yan
关键词:Carcass characteristic; Meat quality; Nutritional ingredients; Amino acids composition; Fatty acids composition; Indigenous Chinese cattle breeds; Beef industry
-
Comparative plastomes of Pueraria montana var. lobata (Leguminosae: Phaseoleae) and closely related taxa: insights into phylogenomic implications and evolutionary divergence
作者:Zhou, Yun;Shang, Xiao-Hong;Xiao, Liang;Wu, Zheng-Dan;Cao, Sheng;Yan, Hua-Bing
关键词:Kudzu; Plastomes; Phylogeny; Pueraria; Genome comparison
-
Selection and validation of internal control genes for quantitative real-time RT-qPCR normalization of Phlebopus portentosus gene expression under different conditions
作者:Hu, Chen-Menghui;Zhou, Chen-Li;Wan, Jia-Ning;Guo, Ting;Tan, Qi;Bao, Da-Peng;Yang, Rui-Heng;Ji, Guang-Yan;Luo, Shun-Zhen;Ji, Kai-Ping;Cao, Yang
关键词:
-
The woody plant-degrading pathogen Lasiodiplodia theobromae effector LtCre1 targets the grapevine sugar-signaling protein VvRHIP1 to suppress host immunity
作者:Xing, Qikai;Cao, Yang;Peng, Junbo;Zhang, Wei;Wang, Xuncheng;Wu, Jiahong;Li, Xinghong;Yan, Jiye;Zhou, Xiangui;Zhou, Xiangui
关键词:Fungal effector; grapevine; Lasiodiplodia theobromae; plant immunity; plant-pathogen interaction; sugar signaling; susceptibility; Vitis vinifera