Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo

文献类型： 外文期刊

第一作者： Zhang, Wei Kevin

作者： Zhang, Wei Kevin;Tao, Shan-Shan;Li, Ting-Ting;Li, Yu-Sang;Li, Xiao-Jun;Tang, He-Bin;Cong, Ren-Huai;Ma, Fang-Li;Cong, Ren-Huai;Ma, Fang-Li;Wan, Chu-Jun

作者机构：

关键词： nutmeg oil;chronic pain;allodynia;COX-2;substance P

期刊名称：FOOD & NUTRITION RESEARCH （ 影响因子：3.894； 五年影响因子：4.442 ）

ISSN： 1654-6628

年卷期： 2016 年 60 卷

页码：

收录情况： SCI

摘要： Background: Chronic pain, or sometimes referred to as persistent pain, reduces the life quality of patients who are suffering from chronic diseases such as inflammatory diseases, cancer and diabetes. Hence, herbal medicines draw many attentions and have been shown effective in the treatment or relief of pain. Methods and Results: Here in this study, we used the CFA-injected rats as a sustainable pain model to test the anti-inflammatory and analgesic effect of nutmeg oil, a spice flavor additive to beverages and baked goods produced from the seed of Myristica fragrans tree. Conclusions: We have demonstrated that nutmeg oil could potentially alleviate the CFA-injection induced joint swelling, mechanical allodynia and heat hyperanalgesia of rats through inhibition of COX-2 expression and blood substance P level, which made it possible for nutmeg oil to be a potential chronic pain reliever.

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