Recent advances in glycoside hydrolase family 20 and 84 inhibitors: Structures, inhibitory mechanisms and biological activities
文献类型: 外文期刊
第一作者: Jiang, Xi
作者: Jiang, Xi;Yang, Qing;Yang, Qing
作者机构:
关键词: Glycoside hydrolase; Hex; OGA; Inhibitor; Inhibitory mechanism; Biological activity
期刊名称:BIOORGANIC CHEMISTRY ( 影响因子:5.1; 五年影响因子:5.3 )
ISSN: 0045-2068
年卷期: 2024 年 142 卷
页码:
收录情况: SCI
摘要: Glycoside hydrolase family 20 (GH20) beta-N-acetyl-D-hexosaminidase (Hex) catalyzes the cleavage of glycosidic linkages in glycans, glycolipids and glycoproteins, and is involved in glycoprotein modification, metabolism of glycoconjugate and the degradation of chitin in fungal cell walls and arthropod exoskeletons. GH84 O-beta-N-acetylD-glucosaminidase (OGA), which is mechanistically similar related to GH20, participates in the O-GlcNAcylation modification, hydrolyzing the O-GlcNAc moiety from protein acceptors. Hex and OGA are of interest due to their potential for the treatment of disorder diseases and plant protection. Hex inhibitors act as molecular chaperones to treat lysosomal storage disease and as growth regulators to arrest insect molting. Inhibition of OGA is a promising therapeutic approach to treat tau pathology in neurodegenerative diseases such as Alzheimer's disease. However, since Hex and OGA exhibit similar active sites, there are challenges in designing highly selective inhibitors. The elucidation of the structural basis of the catalytic mechanism and substrate binding mode of Hex and OGA has provided core information for virtual screening and rational design of inhibitors. A large number of high-potency and selective inhibitors have been developed in the last five years. In this review, we focus on the recent advances in the structural modification, inhibitory activity, binding mechanisms and biological evaluation of Hex and OGA inhibitors, which will facilitate the development of new drugs and agrochemicals.
分类号:
- 相关文献
作者其他论文 更多>>
-
Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment
作者:Zhuang, Zheng;Zhong, Xueqing;Li, Qinghua;Lin, Guo-Qiang;He, Qing-Li;Zhao, Qunfei;Yang, Qing;Liu, Wen;Liu, Tian
关键词:Antifungal biopesticide; Physcion; Microbial production
-
Phloretin alleviates palmitic acid-induced oxidative stress in HUVEC cells by suppressing the expression of LncBAG6-AS
作者:Li, Jie;Yang, Qing;Lan, Xianyong;Yang, Qing;Han, Lin;Yang, Qing;Liu, Hongfei
关键词:
-
Nicosulfuron stress on the glyoxalase system and endogenous hormone content in sweet maize seedlings
作者:Wu, Zhen-Xing;Wang, Ting-Zhen;Chen, Jian-Jian;Li, Xiang-Nan;Lv, Gui-Hua;Wang, Jian;Lin, Xiao-Hu;Yang, Qing;Guan, Yuan
关键词:Nicosulfuron; Sweet corn; Glyoxalase system; Hormone; Gene expression
-
Sorbitol induces flower bud formation via the MADS-box transcription factor EjCAL in loquat
作者:Xu, Hong-Xia;Li, Xiao-Ying;Ge, Hang;Chen, Jun-Wei;Meng, Dong;Yang, Qing;Chen, Ting;Qi, Meng;Meng, Dong;Yang, Qing;Chen, Ting;Qi, Meng
关键词:EjCAL; flower bud differentiation; hyperoside; loquat; sorbitol
-
Chitinase is a Potent Insecticidal Molecular Target of Camptothecin and Its Derivatives
作者:Ding, Yi;Chen, Sizhe;Li, Wenda;Liu, Tian;Yang, Qing;Zhang, Feng;Ge, Guangbo;Yang, Qing
关键词:chitinase; molecular target; inhibitor; insecticide; camptothecin
-
Design, Synthesis, and Biological Activity of Novel Benzo[d][1,3]dioxole-6-benzamide Derivatives: Multichitinase Inhibitors as Potential Insect Growth Regulator Candidates
作者:Jin, Xiaoyu;Sun, Tengda;Guo, Bingbo;Cui, Jialin;Ling, Yun;Zhang, Li;Yang, Xinling;Yang, Qing;Chen, Wei
关键词:insect growth regulators; multichitinase inhibitors; rational design; insecticidal activity; inhibitorymechanism
-
Development of SNP marker panels for genotyping by target sequencing (GBTS) and its application in soybean
作者:Yang, Qing;Shi, Xiaolei;Qin, Jun;Zhang, Mengchen;Yang, Chunyan;Yan, Long;Zhang, Jianan;Chen, Lei;Song, Qijian
关键词:Soybean breeding; Marker-assisted selection (MAS); SNP marker panel; Genotyping by target sequencing (GBTS); Germplasm evaluation; QTL identification