Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment

文献类型： 外文期刊

第一作者： Zhuang, Zheng

作者： Zhuang, Zheng;Zhong, Xueqing;Li, Qinghua;Lin, Guo-Qiang;He, Qing-Li;Zhao, Qunfei;Yang, Qing;Liu, Wen;Liu, Tian

作者机构：

关键词： Antifungal biopesticide; Physcion; Microbial production

期刊名称：BIORESOURCES AND BIOPROCESSING （ 影响因子：4.6； 五年影响因子：6.1 ）

ISSN：

年卷期： 2023 年 10 卷 1 期

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收录情况： SCI

摘要： Physcion is an anthraquinone compound observed dominantly in medicinal herbs. This anthraquinone possesses a variety of pharmaceutically important activities and has been developed to be a widely used antifungal biopesticide. Herein, we report on the effective preparation of 3R-torosachrysone (4), a tetrahydroanthracene precursor of physcion, in Aspergillus oryzae NSAR1 by heterologous expression of related genes mined from the phlegmacins-producing ascomycete Talaromyces sp. F08Z-0631. Conditions for converting 4 into physcion were studied and optimized, leading to the development of a concise approach for extracting high-purity physcion from the alkali-treated fermentation broth of the 4-producing A. oryzae strain.

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