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Cationic polysaccharide nanogels for protein delivery

文献类型: 会议论文

第一作者: Hirohito Avame

作者: Hirohito Avame 1 ; Wakiko Asayama 2 ; Nobuyuki Morimoto; Kazunari Akiyoshi;

作者机构: 1.Institute of Biomaterials & Bioengineering, Tokyo Medical and Dental University, 2-3-10, Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan

2.Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and B

会议名称: Controlled Release Society Annual Meeting and Exposition; 20070707-11; Long Beach,CA(US)

主办单位:

页码: 361-

摘要: Interaction between nanogel of amino group-modified cholesterol-bearing pullulan and FITC-BSA was investigated by fluorescence resonance energy transfer (FRET) and by fluorescence correlation spectroscopy (FCS). CHPNH_2 nanogels efficiently bound BSA (Kd = <1 ×10~(-10) M). Enzyme activity of β-Gal inside a cell was retained after CHPNH_2 nanogel mediated-intracellular delivery.

分类号: [ "Q81" , "Q81"]

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