文献类型： 会议论文

第一作者： Nobuyuki Morimoto

作者： Nobuyuki Morimoto ¹ ; Shin-ichiro M. Nomura ¹ ; NaomiMiyazawa ¹ ; Kazunari Akiyoshi ¹ ;

作者机构： 1.Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University, 2-3-10, Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan

会议名称： Polymeric drug delivery II :

主办单位：

页码： 88-101

摘要： Functional nanogels and hydrogels, based on self-assembly of associating polymers, were designed for novel drug delivery applications. In particular, hydrophobized polysaccharides such as cholesteryl-bearing pullulans form physically cross-linked nanogels by self-assembly. These nanogels trap hydro-phobic molecules (antitumor drugs), proteins (enzymes, insulin, antigen protein), and nucleic acids (DNA plasmids), and therefore, can be used as polymeric nanocarriers in cancer chemotherapy, protein delivery, and artificial vaccines. Stimuli-responsive nanogels such as pH-responsive, thermo-responsive, and photoresponsive nanogels were also designed using a similar self-assembly method. Macrogels with well-defined nanostmctures were obtained by self-assembly, utili?zing these nanogels as building blocks. The self-assembly method based on associating polymers is an efficient and versatile technique for the preparation of functional nanogels and hydrogels.

分类号： R94