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Contribution of Surface Charge to Bovine Serum Albumin Adsorption on Hydroxyapatite Ceramic Particles

文献类型： 会议论文

第一作者： X.D. Zhu

作者： X.D. Zhu 1 ; H.S. Fan 2 ; X.N. Chen; D.X. Li; X.D. Zhang;

作者机构： 1.National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China

2.Sichuan Institute of Chinese Materia Medica, Chengdu, China

关键词： hydroxyapatite;BSA adsorption;zeta potential;electrostatic interaction

会议名称： Bioceramics vol.19 pt.2

主办单位：

页码： 861,864-

摘要： Protein adsorption is driven by various interactions. The contribution of surface charge to bovine serum albumin (BSA) adsorption on hydroxyapatite (HA) ceramic was investigated by adjusting the liquid environment in which the solid particles dispersed. Zeta potentials of HA and the adsorption of BSA on the surface were tested as a function of pH, ionic strength, Ca~(2+) and PO_4~(3-) concentrations in the aqueous solutions, and the results showed that both of them were greatly affected by those experimental variations. Besides, the amount of adsorbed BSA was related to the variation of zeta potential of HA, as could be well understood in terms of electrostatic interactions.

分类号： [ "R318.08" , "R318.08"]

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