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Mechanisms and phenotype of resistance against Erythromycin in Streptococcus suis

文献类型： 会议论文

第一作者： LI Yan-hua

作者： LI Yan-hua 1 ; JIANG Cheng-gang 2 ; CAI Xue-hui 3 ; TONG Guang-zhi; TONG Heng-min;

作者机构： 1.Colleage of Animal Medicine Science, Northeast Agriculture of University,Harbin, 150030,P.R.China

2.Harbin Veterinary Research Institute of China Agriculture Academy Science(CAAS), Harbin, 150001, ,P.R.China

3.Harbin Veterinary Research Institute of Chin

会议名称： Asian Pig Veterinary Society Congress; 20070422-25; Wuhan(CN)

主办单位：

页码： 481-

摘要： Streptococcus suist an important pathogen of pigs, is endemic in most pig-rearing countries of the world. Autogenous vaccines are used to protect swine against S. suis infections but protection is incomplete. Among antimicrobial agents for treatment and prevention, the most active are penicillin and erythromycin . Streptococcus suis resistance to erythromycin have increased recently.Pneumococcal resistance to macrolides is due to either target site modification or active efflux (Weisblum, B,2000). The former, prevalent mechanism usually depends on methylase-mediated modification of 23S rRNA encoded by the erm(B) gene (Leclercq, R,2002;).mn(B)-associated coresistance to macrolide.lincosamide, and streptogramin B (MLS) antibiotics can be expressed either constitutrvely, with high-level resistance to all MLS antibiotics (cMLS phenotype), or inducibly (iMLS phenotype). What is resistance mechanism and phenotype of Streptococcus suis in China? We have undertaken a study to determine the erythromycin susceptibility of 8 5. suis strains isolated in China in 2004 and to identify the mechanism and phenotype of resistance.

分类号： [ "S85" , "S85"]

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