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Changes in Cd4~+ and Cd8~+ T-Cell Subpopulations in Chickens Vaccinated with La Sota or V4 Strains of Ndv

文献类型： 会议论文

第一作者： SUN Jian-hong

作者： SUN Jian-hong 1 ; CAO Dian-jun; LIU Pei-xin; YAN Li-hui; CHEN Jie; KONG Xian-gang; TONG Guang-zhi; LIU Bao-quan; 中国科学院文献情报中心; 中国生物技术发展中心; 中国生物工程学会;;

作者机构： 1.National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the CAAS Harbin 150001, China

关键词： NDV;La Sota V4;vaccine;CD4~+ T;CD8~+ T

会议名称： China Biotechnology 2005 vol.25 Supplement:Research and Progress of Modern Agro-Biotechnology Proceedings of International Agro-Biotechnology Conference 2005

主办单位：

页码： 293-299

摘要： The host cell-mediated-immune response in chickens following immunization with the La Sota or V4 strain of Newcastle disease virus ( NDV) was compared by measuring changes of the percentages of CD4~+ and CD8~+ T lymphocytes in PBLs and spleens by flow cytometric analysis. The results showed that in both La Sota and V4 vaccinated chickens the percentage of CD4~+ T lymphocytes in PBLs was increased significantly at 3 days post-inoculation ( PI) , while the percentage of CD8~+ T lymphocytes was decreased at 3 days PI. Relatively higher percentages of CD4~+ and CD8~+ T lymphocytes were observed in PBLs and spleens of chickens vaccinated with the V4 strain, as compared with the La Sota strain, which could be due to a more vigorous lymphocyte proliferation response following exposure to the V4 strain as compared to La Sota. Differences in CD4~+ and CD8~+ T lymphocyte percentage distributions between La Sota and V4 vaccinated chickens were also noted following virulent virus challenge. The percentage of CD4~+ T lymphocytes in PBLs of chickens vaccinated with La Sota strain following challenge was higher than those vaccinated with V4 strain, while the percentages of splenic CD8~+ T lymphocytes in chickens vaccinated with V4 were higher at 3 and 8 days post-challenge, but lower at 1 day post-challenge than La Sota vaccinated chickens.

分类号： S18

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