文献类型： 会议论文

第一作者： Flavio Esposito

作者： Flavio Esposito ¹ ; Lucia Sansone ² ; Anubhav Srivastava ¹ ; Angela Maria Cusano ³ ; Stefania Campopiano ¹ ; Michele Giordano ² ; Agostino Iadicicco ¹ ;

作者机构： 1.Department of Engineering, University of Naples "Parthenope", Napoli, Italy

2.Institute for Polymers, Composites and Biomaterials, National Research Council of Italy (CNR), Portici, Italy

3.Regional Centre on Information Communication Technology (CeRICT) Scrl, Benevento, Italy

会议名称： IEEE Sensors Conference

主办单位：

页码： 994-997

摘要： We report here about the development of a fiber optic biosensor for the detection of vitamin D. The sensing platform is based on a long period grating (LPG) inscribed into a specialty double cladding fiber, whose sensitivity is enhanced through the mode transition phenomenon by chemical etching of the fiber outer cladding. The LPG is further covered with a nanosized layer of graphene oxide, providing carboxylic functional groups for the covalent immobilization of a vitamin D specific antibody. The testing was conducted using the major circulating form of vitamin D3, i.e., 25-OH-D3 (molecular weight ～400 Da), for which concentrations within 10-1000 ng/mL in buffer solution were measured. A limit of detection of medical interest lower than 10 ng/mL was attained.

分类号： TP212-53