您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Deterministic vs stochastic formulations and qualitative analysis of a recent tumour growth model

文献类型： 会议论文

第一作者： Alessandro Borri

作者： Alessandro Borri 1 ; Pasquale Palumbo 2 ; Federico Papa 3 ;

作者机构： 1.CNR-IASI Biomathematics Laboratory, National Research Council of Italy

2.Department of Biotechnology and Biosciences, University of Milano-Bicocca

3.CNR-IASI, National Research Council of Italy

关键词： Tumour growth control;Chemical master equations;Qualitative behavior analysis

会议名称： IFAC World Congress

主办单位：

页码： 16418-16423

摘要： Mathematical modeling and control have recently played a pivotal role in the understanding of tumour growth and in treatment planning, with a special emphasis in the search for personalized therapies. In this note a recent tumour growth model is investigated. The model entails the proliferating and necrotic tumour cells dynamics, as well as the administered drug level. Inspired by a recent reaction-rate characterization of the model, the approach is further deepened with respect to cells and drug molecules copy numbers, hence resulting relevant under the double facet of the deterministic and stochastic frameworks. With regards to the deterministic model, the qualitative behavior analysis is carried out under the basic assumption of a baseline drug delivery: results are encouraging, since they show which parameter space regions allow effective control law results. Stochastic simulations are carried out by properly exploiting parameter values taken from the available experimental literature, and are consistent with the average value evolution inferred from the deterministic approach, paving the way to further stochastic investigation oriented to frameworks involving a reduced copy number.

分类号： TP273-53

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台