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Adaptive responses of cancer cells to tumor microenvironment changes: an evolutionary model perspective

文献类型: 会议论文

第一作者: Chiara Romano

作者: Chiara Romano 1 ; Alessandro Borri 2 ; Maria Domenica Di Benedetto 1 ;

作者机构: 1.Department of Information Engineering, Computer Science, and Mathematics, Center of Excellence for Research DEWS, University of L’Aquila, Italy

2.CNR-IASI Biomathematics Laboratory, National Research Council of Italy, Rome, Italy

关键词: Analytical models;Adaptation models;Evolution (biology);Biological system modeling;Hypoxia;Data models;Biological cells;Cancer;Tumors;Immune system

会议名称: [ "International Conference on Automation Science and Engineering" , "IEEE International Conference on Automation Science and Engineering"]

主办单位:

页码: 2079-2084

摘要: Evolution has always driven species change. The most interesting manifestations of evolution arise from natural selection, that favors the settling of more suitable species at the expense of others. This also occurs in cancer, where the hostile environment drives cancer cells to evolve to acquire favorable traits, phenotypes, in order to enlarge their species. A therapy can render the environment hostile, thus the physicians role in limiting cell growth while considering their evolution is crucial. In this paper, we focus on the formalization and analysis of a novel eco-evolutionary model of cancer cells, enriched by biological considerations. Simulations validate the model and show how the role of the treatment is crucial in driving cellular dynamics.

分类号: tp2

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