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Regulating Cellular Function Through Physicomechanical Engineering of the Nanobiointerface

文献类型： 会议论文

第一作者： Manus Biggs

作者： Manus Biggs 1 ; Shalom Wind 2 ; Matthew Dalby 3 ; Abhay Pandit 1 ;

作者机构： 1.Network of Excellence for Functional Biomaterials, National University of Ireland, Galway, Ireland

2.Department of Applied Physics and Applied Mathematics, Columbia University, NY, USA

3.Centre for Cell Engineering, Institute of Molecular, Cell and Systems Biology, University of Glasgow, UK

会议名称： European Conference on Biomaterials

主办单位：

页码： 422-

摘要： MSC's respond to submicron scale topography and rigidity through differential focal adhesion formation. Furthermore, our studies indicate a submicron scale for a rigidity dependent contractile unit of the focal adhesion with which cells perceive discrete regions of altered rigidity. Future work will investigate the role of heterogeneous rigidity coupled with nanoscale topography in modulating the cellular phenotype and the translation of nanoscale topography to electrically conducting systems with aim to fabricating next-generation neuroelectrodes.

分类号： Q691

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