您好,欢迎访问中国农业科学院 机构知识库!

Perchlorate-Induced Oxidative Stress in Isolated Liver Mitochondria Responsible for Apoptosis in Primary Cultured Hepatocytes

文献类型: 会议论文

第一作者: Xiao-Hu Zhao

作者: Xiao-Hu Zhao 1 ; Pei-Jiang Zhou 1 ; Xiu Chen 1 ;

作者机构: 1.School of Resources and Environmental Sciences,Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory,Wuhan University,Wuhan 430079,China

关键词: Perchlorate;Oxidative stress;Mitochondria;Hepatocytes;Apoptosis

会议名称: International conference on pollution ecology

主办单位:

页码: 27-27

摘要: The Perchlorate (ClO4-) has been manifested that it could inhibit thyroid hormone synthesis.However,little is known about the effects of the Perchlorate on cell and organelle.To investigate whether Perchlorate exposure causes cytotoxicity in fish by inducing oxidative stress,the primary cultured hepatocytes isolated from Carassius auratus and were incubated with different concentrations (0-10 mmol L-1) of the Perchlorate at 25℃ for 12 h in vitro.In addition,to elucidate the precise mechanism of the Perchlorate induced oxidative stress in mitochondria responsible for toxicity in hepatocytes,isolated liver mitochondria were incubated with different concentrations (0-1000 μmol L-1) of the Perchlorate.

分类号: q958.116

  • 相关文献

[1]Oxidative Stress Mediated Cytotoxicity of Perchlorate in Fish Primary Cultured Hepatocytes. Xiao-Hu Zhao,Pei-Jiang Zhou,Xiu Chen. 2012

[2]Protective Effects of Piceatannol against Beta-Amyloid-Induced Neuronal Cell Death. HYO JIN KIM,KI WON LEE,HYONG JOO LEE,New York Academy of Sciences;. 2007

[3]Aluminum chloride caused liver dysfunction and mitochondrial energy metabolism disorder in rat. Xu, Feibo,Liu, Yanfen,Yu, Kaiyuan,Song, Miao,Li, Yanfei,Liu, Yanfen,Zhu, Yanzhu,Zhao, Hansong.

[4]AlCl3 induces lymphocyte apoptosis in rats through the mitochondria-caspase dependent pathway. Li, Miao,Song, Miao,Ren, Li-Min,Xiu, Chun-Yu,Liu, Jian-Yu,Li, Yan-Fei,Liu, Jian-Yu,Zhu, Yan-zhu.

[5]Oxidative Stress-Mediated Cytotoxicity of Cadmium in Chicken Splenic Lymphocytes. Li, Jin-Long,Tang, Zhao-Xin,Li, Jin-Long,Li, Shu,Xu, Shi-Wen,Li, Hui-Xin,Wang, Xiao-Long. 2010

[6]Rhizoma smilacis glabrae protects rats with gentamicin-induced kidney injury from oxidative stress-induced apoptosis by inhibiting caspase-3 activation. Liu, Cuiyan,Kang, Youxi,Yang, Zisheng,Han, Chunyang,Zhou, Xiuhong,Gu, Jingang.

[7]Cytoprotective effect of deferiprone against aluminum chloride-induced oxidative stress and apoptosis in lymphocytes. Zhuang, Cuicui,Zhang, Haiyang,Song, Miao,Han, Yanfei,Li, Yanfei,She, Yue,Zhu, Yanzhu. 2018

[8]Long-term High-fat High-sucrose Diet Promotes Enlarged Islets and beta-Cell Damage by Oxidative Stress in Bama Minipigs. Zhao, Zhan-zhao,Xin, Lei-lei,Xia, Ji-han,Yang, Shu-lin,Li, Kui,Zhao, Zhan-zhao,Chen, Yao-xing. 2015

[9]Protective Effects of Cynaroside Against H2O2-Induced Apoptosis in H9c2 Cardiomyoblasts. Sun, Xiao-bo,Sun, Xiao-bo. 2011

[10]An isoflavonoid-enriched extract from Pueraria lobata (kudzu) root protects human umbilical vein endothelial cells against oxidative stress induced apoptosis. Gao, Ying,Gao, Ying,Wang, Xu,He, Chunnian.

[11]非RIG-I依赖的鸡STING介导干扰素产生的信号通路. 程玉强,孙英杰,王恒安,严亚贤,丁铲,孙建和. 2015

[12]Biological characterization of liver fatty acid binding gene from miniature pig liver cDNA library. Gao, Y. H.,Wang, K. F.,Zhang, S.,Fan, Y. N.,Guan, W. J.,Ma, Y. H.,Gao, Y. H.,Wang, K. F.,Zhang, S.,Fan, Y. N.. 2015

[13]Purification, characterisation and protective effects of polysaccharides from alfalfa on hepatocytes. Wang, Shaopu,Dong, Xiaofang,Cui, Yaoming,Tong, Jianming,Ma, Hao.

[14]Antioxidant and anti-inflammatory effects of Chinese propolis during palmitic acid-induced lipotoxicity in cultured hepatocytes. Jin, Xiao-Lu,Wang, Kai,Li, Qiang-Qiang,Tian, Wen-Li,Xue, Xiao-Feng,Wu, Li-Ming,Jin, Xiao-Lu,Hu, Fu-Liang.

[15]A Primary Experiment of Perchlorate Reduction by Photocatalyst. Jie YAO,Huailong SU,Hong YOU,Long YE,Yuehu WANG,Erping LI. 2011

[16]Induction of Apoptosis and Inhibitionof Invasion in Human Hepatoma Cellsby Anthocyanins from Meoru. Dong Yeok Shin,Chung Ho Ryu,Won Sup Lee,Dong Chul Kim,Seok Hyun Kim,Young-Sool Hah,Sung Joong Lee,Sung Chul Shin,Ho Sung Kang,Yung Hyun Choi. 2009

[17]Reduced mitochondrial and ascorbate-glutathione activity after artificial ageing in soybean seed. Xin, Xia,Tian, Qian,Yin, Guangkun,Chen, Xiaoling,Zhang, Jinmei,Lu, Xinxiong,Tian, Qian,Ng, Sophia,Ng, Sophia. 2014

[18]The E-Subgroup Pentatricopeptide Repeat Protein Family in Arabidopsis thaliana and Confirmation of the Responsiveness PPR96 to Abiotic Stresses. Liu, Jia-Ming,Zhao, Juan-Ying,Guo, Chang-Hong,Liu, Jia-Ming,Zhao, Juan-Ying,Lu, Pan-Pan,Chen, Ming,Xu, Zhao-Shi,Ma, You-Zhi. 2016

[19]iTRAQ Mitoproteome Analysis Reveals Mechanisms of Programmed Cell Death in Arabidopsis thaliana Induced by Ochratoxin A. Xu, Wentao,Luo, Yunbo,Huang, Kunlun,Wang, Yan,Wang, Yan,Peng, Xiaoli,Yang, Zhuojun,Zhao, Weiwei,Xu, Wentao,Hao, Junran,Wu, Weihong,Shen, Xiao Li,Luo, Yunbo,Huang, Kunlun,Peng, Xiaoli,Shen, Xiao Li. 2017

[20]Mitochondrial proteins differential expression during honeybee (Apis mellifera L.) queen and worker larvae caste determination. Begna, Desalegn,Fang, Yu,Feng, Mao,Li, Jianke.

作者其他论文 更多>>