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Morphology of urethral tissues

文献类型： 会议论文

第一作者： Bert Muller

作者： Bert Muller 1 ; Georg Schulz 1 ; Julia Herzen 2 ; Shpend Mushkolaj 1 ; Therese Bormann 1 ; Felix Beckmann 2 ; Klaus Puschel 3 ;

作者机构： 1.Biomaterials Science Center, University of Basel, 4031 Basel, Switzerland

2.Institute for Materials Research, GKSS-Research Centre, 21502 Geesthacht, Germany

3.Institute for Legal Medicine, University Hospital Hamburg-Eppendorf, 22529 Hamburg, Germany

关键词： urethra;micro computed tomography;grating interferometry;urinary incontinence

会议名称： SPIE Conference on Developments in X-ray Tomography

主办单位：

页码： 78040D:1-78040D:12

摘要： Micro computed tomography has been developed to a powerful technique for the characterization of hard and soft human and animal tissues. Soft tissues including the urethra, however, are difficult to be analyzed, since the microstructures of interest exhibit X-ray absorption values very similar to the surroundings. Selective staining using highly absorbing species is a widely used approach, but associated with significant tissue modification. Alternatively, one can suitably embed the soft tissue, which requires the exchange of water. Therefore, the more recently developed phase contrast modes providing much better contrast of low X-ray absorbing species are especially accommodating in soft tissue characterization. The present communication deals with the morphological characterization of sheep, pig and human urethras on the micrometer scale taking advantage of micro computed tomography in absorption and phase contrast modes. The performance of grating-based tomography is demonstrated for freshly explanted male and female urethras in saline solution. The micro-morphology of the urethra is important to understand how the muscles close the urethra to reach continence. As the number of incontinent patients is steadily increasing, the function under static and, more important, under stress conditions has to be uncovered for the realization of artificial urinary sphincters, which needs sophisticated, biologically inspired concepts to become nature analogue.

分类号： N-532

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