A lysosomal localized fluorescence probe for the detection of formaldehyde and its cell imaging
文献类型： 外文期刊
作者： Wang, Min 1 ; Zhang, Xiao 3 ; Wang, Le 3 ; Zhang, Jingyi 1 ; Liu, Na 1 ; Zhang, Di 2 ;
作者机构： 1.Zhengzhou Normal Univ, Coll Chem & Chem Engn, Zhengzhou 450044, Peoples R China
2.Henan Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Zhengzhou 450002, Peoples R China
3.Shanghai Univ Engn Sci, Coll Chem & Chem Engn, Shanghai 201620, Peoples R China
关键词： Formaldehyde; Fluorescence probe; Lysosome-targeted
期刊名称：MICROCHEMICAL JOURNAL （ 影响因子：4.8； 五年影响因子：4.5 ）
ISSN： 0026-265X
年卷期： 2023 年 191 卷
页码：
收录情况： SCI
摘要： Formaldehyde (FA) is one of reactive carbonyl species (RCS), which is involved in various physiological and pathological processes of organisms. Herein, a novel fluorescent probe (FAP1) containing lysosomal localization group for the detection of FA was designed and synthesized. The probe exhibited good fluorescence recognition performances for FA, such as large Stokes shift (130 nm), specific selectivity, good anti-interference ability, and low minimum detection limit (16 nM). It is worth mentioning that the probe has good biocompatibility and could be applied to the imaging detection of FA in lysosome.
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