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Claudin-11 plays a pivotal role in the clathrin-mediated endocytosis of influenza A virus

文献类型： 外文期刊

作者： Yu, Xiaofei 1 ; Ni, Zixin 2 ; Wang, Yifan 2 ; Wang, Jingfei 2 ; Deng, Guohua 2 ; Shi, Jianzhong 2 ; Kong, Huihui 2 ; Jiang, Yongping 2 ; Tian, Guobin 2 ; Li, Chengjun 2 ; Kawaoka, Yoshihiro 3 ; Chen, Hualan 1 ; Wang, Jinliang 2 ;

作者机构： 1.China Agr Univ, Coll Vet Med, Key Lab Prevent & Control Avian Influenza & Other, Minist Agr & Rural Affairs, Beijing 100193, Peoples R China

2.Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Harbin 150069, Peoples R China

3.Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Dept Microbiol & Immunol,Div Virol, Tokyo 1088639, Japan

关键词： influenza A virus; claudin-11; clathrin-mediated endocytosis; mGluR2; KCa1.1; pathogenicity

期刊名称：SCIENCE CHINA-LIFE SCIENCES （ 影响因子：9.5； 五年影响因子：8.1 ）

ISSN： 1674-7305

年卷期： 2025 年 68 卷 5 期

页码：

收录情况： SCI

摘要： Identification of host factors that play a key role in viral replication is of great importance for antiviral development. Metabotropic glutamate receptor subtype 2 (mGluR2) is the receptor to trigger clathrin-mediated endocytosis (CME), the major pathway by which influenza virus enters cells. However, other host factors almost certainly involved in the influenza virus CME are largely unknown. Here, we found that the four-transmembrane protein claudin-11 plays an integral part in influenza virus CME. Claudin-11 promotes the dissociation of KCa1.1 (potassium calcium-activated channel subfamily M alpha 1) from mGluR2 and, together with mGluR2, is internalized in virus-containing clathrin-coated pits (CCPs), where it regulates the depolymerization of polymerized F-actin, allowing the CCPs to mature. Importantly, over 60% of claudin-11-silenced mice survived infection with a lethal influenza virus. Our findings advance the understanding of influenza virus infection and provide a promising strategy for the development of host-based antiviral drugs.

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