Pathogenicity and Whole Genome Sequence Analysis of a Pseudorabies Virus Strain FJ-2012 Isolated from Fujian, Southern China
文献类型： 外文期刊
作者： Wu, Xue-min 1 ; Chen, Qiu-yong 1 ; Chen, Ru-jing 1 ; Che, Yong-liang 1 ; Wang, Long-bai 1 ; Wang, Chen-yan 1 ; Yan, Sh 1 ;
作者机构： 1.Fujian Acad Agr Sci, Fujian Anim Dis Control Technol Dev Ctr, Inst Anim Husb & Vet Med, Fuzhou 350002, Fujian, Peoples R China
期刊名称：CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY （ 影响因子：2.471； 五年影响因子：2.242 ）
ISSN： 1712-9532
年卷期： 2017 年
页码：
收录情况： SCI
摘要： The outbreaks of pseudorabies have been frequently reported in Bartha-K61-vaccinated farms in China since 2011. To study the pathogenicity and evolution of the circulating pseudorabies viruses in Fujian Province, mainland China, we isolated and sequenced the whole genome of a wild-type pseudorabies virus strain named FJ-2012. We then conducted a few downstream bioinformatics analyses including phylogenetic analysis and pathogenic analysis and used the virus to infect 6 pseudorabies virus-free piglets. FJ-2012-infected piglets developed symptoms like high body temperature and central nervous system disorders and had high mortality rate. In addition, we identified typical micropathological changes such as multiple gross lesions in infected piglets through pathological analysis and conclude that the FJ-2012 genome is significantly different from known pseudorabies viruses, in which insertions, deletions, and substitutions are observed in multiple immune and virulence genes. In summary, this study shed lights on the molecular basis of the prevalence and pathology of the pseudorabies virus strain FJ-2012. The genome of FJ-2012 could be used as a reference to study the evolution of pseudorabies viruses, which is critical to the vaccine development of new emerging pseudorabies viruses.
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