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Dynamic N6-methyladenosine RNA modification regulates peanut resistance to bacterial wilt

文献类型： 外文期刊

作者： Zhao, Kai 1 ; Li, Zhongfeng 1 ; Ke, Yunzhuo 2 ; Ren, Rui 1 ; Cao, Zenghui 1 ; Li, Zhan 1 ; Wang, Kuopeng 1 ; Wang, Xiaoxuan 1 ; Wang, Jinzhi 1 ; Ma, Qian 1 ; Cao, Di 1 ; Zhao, Kunkun 1 ; Li, Yaoyao 1 ; Hu, Sasa 1 ; Qiu, Ding 1 ; Gong, Fangping 1 ; Ma, Xingli 1 ; Zhang, Xingguo 1 ; Fan, Guoqiang 3 ; Liang, Zhe 2 ; Yin, Dongmei 1 ;

作者机构： 1.Henan Agr Univ, Coll Agron & Peanut Funct Genome & Mol Breeding En, Zhengzhou 450046, Peoples R China

2.Chinese Acad Agr Sci, Biotechnol Res Inst, Beijing 100081, Peoples R China

3.Henan Agr Univ, Coll Forestry, Zhengzhou 450046, Peoples R China

关键词： bacterial wilt; demethylase; disease resistance; m(6)A modification; peanut

期刊名称：NEW PHYTOLOGIST （ 影响因子：9.4； 五年影响因子：10.5 ）

ISSN： 0028-646X

年卷期： 2024 年 242 卷 1 期

页码：

收录情况： SCI

摘要： N6-methyladenosine (m(6)A) is the most abundant mRNA modification in eukaryotes and is an important regulator of gene expression as well as many other critical biological processes. However, the characteristics and functions of m6A in peanut (Arachis hypogea L.) resistance to bacterial wilt (BW) remain unknown. Here, we analyzed the dynamic of m(6)A during infection of resistant (H108) and susceptible (H107) peanut accessions with Ralstonia solanacearum (R. solanacearum), the causative agent of BW. Throughout the transcriptome, we identified 'URUAY' as a highly conserved motif for m(6)A in peanut. The majority of differential m(6)A located within the 3 ' untranslated region (UTR) of the transcript, with fewer in the exons. Integrative analysis of RNA-Seq and m6A methylomes suggests the correlation between m6A and gene expression in peanut R. solanacearum infection, and functional analysis reveals that m(6)A-associated genes were related to plant-pathogen interaction. Our experimental analysis suggests that AhALKBH15 is an m(6)A demethylase in peanut, leading to decreased m(6)A levels and upregulation of the resistance gene AhCQ2G6Y. The upregulation of AhCQ2G6Y expression appears to promote BW resistance in the H108 accession.

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