文献类型： 外文期刊
作者： Wang, Xiangyu 1 ; Huang, Huanwei 2 ; Jiang, Sanjie 4 ; Kang, Jingmin 5 ; Li, Dongwei 1 ; Wang, Kailai 2 ; Xie, Shang 1 ; Tong, Cheng 1 ; Liu, Chaofan 1 ; Hu, Guihua 1 ; Li, Haoqian 1 ; Li, Cong 1 ; Yang, Liwen 1 ; Ding, Yike 6 ; Li, Shang-Tong 2 ; Wang, Faming 7 ; Lohmann, Jan U. 8 ; Liang, Zhe 1 ; Gu, Xiaofeng 1 ;
作者机构： 1.Chinese Acad Agr Sci, Biotechnol Res Inst, Beijing, Peoples R China
2.Glbizzia Biosci, Beijing, Peoples R China
3.Capital Med Univ, Sch Basic Med Sci, Beijing, Peoples R China
4.BGI Genom, Shenzhen, Peoples R China
5.BGI Res, Beijing, Peoples R China
6.Univ Calif Riverside, Dept Entomol, Riverside, CA USA
7.Katholieke Univ Leuven, Dept Biosyst, Leuven, Belgium
8.Heidelberg Univ, Ctr Organismal Studies, Heidelberg, Germany
期刊名称：NATURE （ 影响因子：48.5； 五年影响因子：55.0 ）
ISSN： 0028-0836
年卷期： 2025 年 644 卷 8077 期
页码：
收录情况： SCI
摘要： Cell functions across eukaryotes are driven by specific gene expression programs, which are dependent on chromatin structure1, 2-3. Here we report a single-cell multi-omics atlas of rice, one of the world's major crops. By simultaneously profiling chromatin accessibility and RNA expression in 116,564 cells from eight organs, we identified cell-type-specific gene regulatory networks and described novel cell states, such as a 'transitional state' in floral meristems. On the basis of our network analyses, we uncovered the function of the cell-type-specific regulatory hubs RSR1, F3H and LTPL120 during rice development. Our analysis revealed correlations between cell type and agronomic traits, as well as conserved and divergent cell-type functions during evolution. In summary, this study not only offers a unique single-cell multi-omics resource for a major crop but also advances our understanding of cell-type functions and the underlying molecular programs in rice.
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