Smartphone-based digital phenotyping for genome-wide association study of intramuscular fat traits in longissimus dorsi muscle of pigs
文献类型： 外文期刊
作者： Shen, Yang 1 ; Chen, Yuxi 2 ; Zhang, Shufeng 2 ; Wu, Ze 2 ; Lu, Xiaoyu 2 ; Liu, Weizhen 2 ; Liu, Bang 1 ; Zhou, Xiang 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Anim Sci & Technol, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan, Peoples R China
2.Wuhan Univ Technol, Sch Comp Sci & Artificial Intelligence, Wuhan, Peoples R China
3.Hubei Hongshan Lab, Wuhan, Peoples R China
4.Huazhong Agr Univ, Shenzhen Inst Nutr & Hlth, Wuhan, Peoples R China
5.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr,Genome Anal Lab,M, Shenzhen, Peoples R China
6.Huazhong Agr Univ, Coll Anim Sci & Technol, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China
关键词： deep learning; GWAS; image analysis; intramuscular fat traits; pig; smartphone application
期刊名称：ANIMAL GENETICS （ 影响因子：2.4； 五年影响因子：2.8 ）
ISSN： 0268-9146
年卷期： 2024 年 55 卷 2 期
页码：
收录情况： SCI
摘要： Intramuscular fat (IMF) content and distribution significantly contribute to the eating quality of pork. However, the current methods used for measuring these traits are complex, time-consuming and costly. To simplify the measurement process, this study developed a smartphone application (App) called Pork IMF. This App serves as a rapid and portable phenotyping tool for acquiring pork images and extracting the image-based IMF traits through embedded deep-learning algorithms. Utilizing this App, we collected the IMF traits of the longissimus dorsi muscle in a crossbred population of Large White x Tongcheng pigs. Genome-wide association studies detected 13 and 16 SNPs that were significantly associated with IMF content and distribution, respectively, highlighting NR2F2, MCTP2, MTLN, ST3GAL5, NDUFAB1 and PID1 as candidate genes. Our research introduces a user-friendly digital phenotyping technology for quantifying IMF traits and suggests candidate genes and SNPs for genetic improvement of IMF traits in pigs.
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