Hesperidin ameliorates H2O2-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway
文献类型： 外文期刊
作者： Huang, Qi 1 ; Liu, Jiashuo 1 ; Peng, Can 1 ; Han, Xuefeng 1 ; Tan, Zhiliang 1 ;
作者机构： 1.Chinese Acad Sci, Natl Engn Lab Pollut Control & Waste Utilizat Live, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, CAS Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop, Changsha 410125, Hunan, Peoples R China
2.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr & Feeding, Beijing 100193, Peoples R China
关键词： Bovine mammary epithelial cell; Hesperidin; Nrf2 signaling pathway; Oxidative stress
期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：7.0； 五年影响因子：7.3 ）
ISSN： 1674-9782
年卷期： 2024 年 15 卷 1 期
页码：
收录情况： SCI
摘要： Background Hesperidin is a citrus flavonoid with anti-inflammatory and antioxidant potential. However, its protective effects on bovine mammary epithelial cells (bMECs) exposed to oxidative stress have not been elucidated. Results In this study, we investigated the effects of hesperidin on H2O2-induced oxidative stress in bMECs and the underlying molecular mechanism. We found that hesperidin attenuated H2O2-induced cell damage by reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels, increasing catalase (CAT) activity, and improving cell proliferation and mitochondrial membrane potential. Moreover, hesperidin activated the Keap1/Nrf2/ARE signaling pathway by inducing the nuclear translocation of Nrf2 and the expression of its downstream genes NQO1 and HO-1, which are antioxidant enzymes involved in ROS scavenging and cellular redox balance. The protective effects of hesperidin were blocked by the Nrf2 inhibitor ML385, indicating that they were Nrf2 dependent. Conclusions Our results suggest that hesperidin could protect bMECs from oxidative stress injury by activating the Nrf2 signaling pathway, suggesting that hesperidin as a natural antioxidant has positive potential as a feed additive or plant drug to promote the health benefits of bovine mammary.
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