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Muscle Transcriptome Analysis of Mink at Different Growth Stages Using RNA-Seq

文献类型： 外文期刊

作者： Rong, Min 1 ; Xing, Xiumei 1 ; Zhang, Ranran 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Changchun 130112, Peoples R China

2.Dezhou Anim Husb & Vet Dev Ctr, Dezhou 253000, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Genet Breeding & Reprod Special Econ Anim, Changchun 130112, Peoples R China

关键词： mink; transcriptomics; muscle development

期刊名称：BIOLOGY-BASEL （ 影响因子：4.2； 五年影响因子：4.4 ）

ISSN：

年卷期： 2024 年 13 卷 5 期

页码：

收录情况： SCI

摘要： Mink is a kind of small and precious fur animal resource. In this study, we employed transcriptomics technology to analyze the gene expression profile of mink pectoral muscle tissue, thereby elucidating the regulatory mechanisms underlying mink growth and development. Consequently, a total of 25,954 gene expression profiles were acquired throughout the growth and development stages of mink at 45, 90, and 120 days. Among these profiles, 2607 genes exhibited significant differential expression (|log2(fold change)| >= 2 and p_adj < 0.05). GO and KEGG enrichment analyses revealed that the differentially expressed genes were primarily associated with the mitotic cell cycle process, response to growth factors, muscle organ development, and insulin resistance. Furthermore, GSEA enrichment analysis demonstrated a significant enrichment of differentially expressed genes in the p53 signaling pathway at 45 days of age. Subsequent analysis revealed that genes associated with embryonic development (e.g., PEG10, IGF2, NRK), cell cycle regulation (e.g., CDK6, CDC6, CDC27, CCNA2), and the FGF family (e.g., FGF2, FGF6, FGFR2) were all found to be upregulated at 45 days of age in mink, which suggested a potential role for these genes in governing early growth and developmental processes. Conversely, genes associated with skeletal muscle development (PRVA, TNNI1, TNNI2, MYL3, MUSTN1), a negative regulator of the cell cycle gene (CDKN2C), and IGFBP6 were found to be up-regulated at 90 days of age, suggesting their potential involvement in the rapid growth of mink. In summary, our experimental data provide robust support for elucidating the regulatory mechanisms underlying the growth and development of mink.

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