您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Mesoporous Potassium-Based Metal-Organic Framework as a Drug Carrier

文献类型： 外文期刊

作者： Fang, Bo 1 ; Shan, Tianyu 2 ; Chen, Sailing 4 ; Pan, Fei 5 ; Yang, Xue 2 ; Xiao, Ding 2 ; Huang, Feihe 2 ; Mao, Zhengwei 1 ;

作者机构： 1.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Hepatobiliary & Pancreat Surg, Hangzhou 310003, Peoples R China

2.Zhejiang Univ, Stoddart Inst Mol Sci, Dept Chem, Hangzhou 310058, Peoples R China

3.Zhejiang Univ, ZJU Hangzhou Global Sci & Technol Innovat Ctr, Zhejiang Israel Joint Lab Self Assembling Funct Ma, Hangzhou 311215, Peoples R China

4.Zhejiang Univ, Womens Hosp, Sch Med, Dept Reprod Endocrinol, Hangzhou 310006, Peoples R China

5.Chinese Acad Agr Sci, State Key Lab Resource Insects, Inst Apicultural Res, Beijing 100093, Peoples R China

6.Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310058, Peoples R China

期刊名称：ACS CENTRAL SCIENCE （ 影响因子：10.4； 五年影响因子：15.2 ）

ISSN： 2374-7943

年卷期： 2025 年

页码：

收录情况： SCI

摘要： To date, the number of reported mesoporous metal-organic frameworks (MOFs) remains limited. Herein, we report a novel mesoporous potassium-based MOF (K-MOF), designated as KMOF-1, whose precise structure was determined by using single-crystal X-ray diffraction. KMOF-1 used 18-crown-6 units as the organic linkers and potassium ions as the metal centers, forming a framework topological structure with interconnected four-membered rings. The specific surface area of the synthesized KMOF-1 was determined by the Brunauer-Emmett-Teller method, which showed a high specific surface area of 1034 m2/g. KMOF-1 was demonstrated to be a promising drug carrier, exhibiting encapsulation capabilities for various drugs and maintaining stability for a defined period under simulated physiological conditions. Using vascular endothelial growth factor (VEGF) aptamers as model drugs, we further confirmed the effective loading of VEGF aptamers in KMOF-1 (KMOF-1@VEGF) and the ability of KMOF-1@VEGF to release VEGF aptamers responsively in acidic environments. Additionally, in vitro studies showed that KMOF-1 protected VEGF aptamers from degradation by nucleases, allowing them to be effectively taken up by cells. This novel K-MOF, with its biocompatible metal centers, mesoporous channels, and demonstrated efficacy as a drug carrier, offers a significant advancement in developing MOF-based drug delivery systems.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台