Hybrid Diterpenic Meroterpenoids from an Endophytic Penicillium sp. Induced by Chemical Epigenetic Manipulation
文献类型： 外文期刊
作者： Li, Changyan 1 ; Shao, Yating 1 ; Li, Wei 1 ; Yin, Tianpeng 3 ; Li, Hongtao 1 ; Yan, Hui 4 ; Guo, Xingyi 1 ; Liu, Bo 1 ; He, Bo 1 ;
作者机构： 1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650031, Yunnan, Peoples R China
2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650031, Yunnan, Peoples R China
3.Zunyi Med Univ, Zhuhai Key Lab Fundamental & Appl Res Tradit Chin, Zhuhai Campus, Zhuhai 519000, Guangdong, Peoples R China
4.Yunnan Acad Agr Sci, Inst Agr Environm & Resources, Kunming 650031, Yunnan, Peoples R China
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.803； 五年影响因子：4.869 ）
ISSN： 0163-3864
年卷期： 2022 年 85 卷 6 期
页码：
收录情况： SCI
摘要： Cultivation of an endophytic fungus Penicillium sp. KMU18029 with suberanilohydroxamic acid (SAHA), a histone deacetylase inhibitor, led to the isolation of two pairs of diterpenic meroterpenoids with a unique natural product framework combining features of pyripyropenes and decaturins/oxalicines, pyrandecarurins A (1) and B (2), pileotin A (3) and B (4), along with their potential precursor decaturenoid (5). Compounds 1, 2, 4, and 5 were new. The structures of 1 -5 were elucidated by extensive spectroscopic analyses. The absolute configurations of 1 -4 were determined by single-crystal X-ray diffraction, NOESY spectra, ECD calculations, and biogenetic considerations. The absolute configuration of compound 3 was confirmed for the first time. Compound 5 showed moderate activity against AChE with an IC50 value of 13.9 +/- 1.1 mu M.
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