Host-similar fragments in the African swine fever virus genome: distribution, functions, and evolution
文献类型： 外文期刊
作者： Zhu, Zhaozhong 1 ; Li, Na 1 ; Sun, Qin 1 ; Long, Xizi 1 ; Wang, Tao 2 ; Qiu, Hua-Ji 2 ;
作者机构： 1.Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Peoples R China
2.Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Natl African Swine Fever Para Reference Lab,Natl H, Harbin, Peoples R China
关键词： African swine fever virus; host-similar fragments; similarity network; evolution; recombination
期刊名称：VETERINARY RESEARCH （ 影响因子：3.5； 五年影响因子：4.0 ）
ISSN： 0928-4249
年卷期： 2025 年 56 卷 1 期
页码：
收录情况： SCI
摘要： African swine fever virus (ASFV) predominantly infects Argasidae and suids, resulting in high morbidity and mortality in pigs. Despite the crucial role that viral sequences resembling those of the host play in the virus's survival, there are limited comprehensive studies on the genomic similarities between ASFV and its hosts. Consequently, this study employs homology analysis to construct a similarity network between ASFV and its hosts (Argasidae and suids), investigating the distribution, function, evolution, and origins of these similar sequences in ASFV. Our findings indicate that the host-similar fragments are mainly distributed between positions 70000 and 180000 of the ASFV genome, primarily within non-coding regions. Notably, these non-coding fragments are often associated with promoter functions. Furthermore, the analysis of suid proteins that share similarities with ASFV proteins reveals that they predominantly exhibit RNA polymerase activity and are involved in metabolic processes. Evolutionary analysis indicates that pan-similar sequences of ASFV exist in an open state, highlighting the diversity of these analogous sequences. Additionally, a positive correlation was identified between the occurrence of recombination breakpoints and similar sequences, indicating that homologous recombination may serve as a crucial mechanism driving the formation of these analogous sequences.
- 相关文献
作者其他论文 更多>>
-
A Novel Land Surface Temperature Retrieval Algorithm for SDGSAT-1 Images
作者：Li, Na;Wang, Yunpeng;Li, Na;Wang, Yunpeng;Li, Na;Xu, Jianhui;Li, Xu;Zhong, Kaiwen;Qin, Zhihao;Qin, Boxiong;Qin, Boxiong;Fu, Dongjie;Fu, Dongjie;Qin, Zhihao
关键词：Land surface temperature; Spatial resolution; Land surface; Grasslands; Sensors; Remote sensing; MODIS; Atmospheric measurements; Landsat; Vegetation mapping; Land surface temperature (LST); retrieval algorithms; Sustainable Development Goals Science Satellite 1 (SDGSAT-1); validation
-
The S273R protein of African swine fever virus antagonizes the canonical NF-κB signaling pathway by IκBα
作者：Ren, Haojie;Shi, Lan-Fang;Pan, Xiao-Ya;Ma, Yu-He;Fan, Jun-Hao;Chen, Xing;Yang, Zhong-Yuan;Fan, Shuai;Zhang, Yuhang;Han, Shichong;He, Wen-Rui;Wan, Bo;Zhang, Gai-Ping;Wang, Yanjin;Li, Su;Qiu, Hua-Ji;Zhang, Yuhang;Han, Shichong;He, Wen-Rui;Wan, Bo;Zhang, Gai-Ping;Zhang, Yuhang;Han, Shichong;He, Wen-Rui;Wan, Bo
关键词：African swine fever virus; canonical NF-
kappa B signaling pathway; S273R protein; Ikappa Balpha ; inflammatory responses -
COP I vesicles facilitate classical swine fever virus proliferation by transporting fatty acid synthase from the Golgi apparatus to the endoplasmic reticulum
作者：Zhang, Liang;Chen, Chen;Song, Mengzhao;Li, Ning;Luo, Bihao;Quan, Yuehan;Guo, Kangkang;Zhang, Yanming;Wang, Tao
关键词：classical swine fever virus; early secretory pathway; coatomer protein I; coatomer protein II; fatty acid synthase
-
Widely Targeted Metabolomic and Network Pharmacology Analyses of Active Compounds Enriched from Ethanolic Extract of Oudemansiella raphanipes
作者：Wu, Zhi;Zhao, Jin;Lin, Junbin;Miao, Renyun;Feng, Rencai;Gan, Bingcheng;Wang, Tao;Zhu, Shuang;Chen, Mengxing;Wu, Dan;Wu, Yiyou;Li, Xiang;Gan, Bingcheng
关键词：
Oudemansiella raphanipes ; widely targeted metabolomics; antioxidant activity; enrichment approaches; network pharmacology -
Identification and Pathogenicity Analysis of Feline Calicivirus in Shanghai and Guangdong, China
作者：Luo, Dan;Xie, Weile;Zhou, Xinchu;Wang, Zhe;Luo, Dan;Xie, Weile;Wang, Zhe;Li, Na;Peng, Xueyan;Li, Kai
关键词：broad-spectrum neutralization; challenge experiments; enteritis; feline calicivirus; phylogenetic analysis; VP1
-
Optimizing a water-saving and salt-controlling irrigation strategy for improving cotton yield with the AquaCrop model under mulched drip irrigation in saline-alkali soil
作者：Jiang, Fuchang;Gao, Yang;Wang, Hongbo;Wang, Xingpeng;Jiang, Fuchang;Gao, Yang;Wang, Hongbo;Wang, Xingpeng;Li, Na;Liang, Jiaping;Li, Na;Liang, Jiaping;Wang, Xingpeng;Gao, Yang;Du, Jiangtao
关键词：
-
On-demand celastrol delivery by hyaluronic acid-porphyrinic metal-organic frameworks for synergistic sonodynamic/pharmacological antibacterial therapy
作者：Wang, Tao;Zhao, Jin;Wu, Zhi;Gan, Bingcheng;Chen, Maohua;Chen, Mengxing;Wu, Dan;Wu, Yiyou;Gan, Bingcheng
关键词：Hyaluronic acid; Metal-organic frameworks; Celastrol
