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Combined transcriptome and metabolome analysis of chicken follicles in Tengchong Snow Chicken follicle selection

文献类型： 外文期刊

作者： Du, Yanli 1 ; Zi, Xiannian 2 ; Wang, Kun 2 ; Ran, Jinshan 1 ; Xiang, Hanyi 3 ; Lei, Li 3 ; Liu, Yong 2 ;

作者机构： 1.Kunming Univ, Coll Agron & Life Sci, Kunming, Peoples R China

2.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming, Peoples R China

3.Yunnan Open Univ, Yunnan Rural Revitalizing Educ Inst, Kunming, Peoples R China

4.Chinese Acad Agr Sci, Guangxi Bufialo Res Inst, Key Lab Buffalo Genet Breeding & Reprod Technol, Nanning, Peoples R China

5.Luxi Kangtai Fruit & Anim Husb Prod & Mkt Co, Luxi, Peoples R China

关键词： Egg-laying Chickens; Follicle; Metabolome Analysis; Reverse Transcription Quantitative Polymerase Chain Reaction; Transcriptome Analysis

期刊名称：ANIMAL BIOSCIENCE （ 影响因子：2.5； 五年影响因子：2.8 ）

ISSN： 2765-0189

年卷期： 2025 年 38 卷 7 期

页码：

收录情况： SCI

摘要： Objective: The development of pre-hierarchical follicles (PHFs), especially small yellow follicles (SYFs), directly affects the recruitment of dominant follicles and subsequently affects the egg-laying performance of chickens. The development of PHFs, especially SYFs, and their regulatory mechanisms remain unclear. Methods: Transcriptomic and metabolomic analyses were conducted on large white follicles (LWFs) and SYFs in chickens. Results: Transcriptome sequencing revealed 258 differentially expressed genes (DEGs) between SYFs and LWFs, with 172 genes upregulated and 86 downregulated. The DEGs were mapped to 17 Kyoto encyclopedia of genes and genomes (KEGG) pathways, including glutathione metabolism, ferroptosis, calcium signaling pathway, and neuroactive ligand- receptor interactions, among others. The metabolome analysis revealed 129 significant differential metabolites (DMs), comprising 36 upregulated and 93 downregulated metabolites. The DMs were associated with nine KEGG pathways, including glutathione metabolism, alpha-linolenic acid metabolism, and linoleic acid metabolism, etc. The combined transcriptional and metabolic analysis revealed significantly enriched pathways. Five KEGG pathways associated with follicular development were identified, including glutathione metabolism, ferroptosis, alpha-linolenic acid metabolism, linoleic acid metabolism, and pyrimidine metabolism. Conclusion: Glutathione metabolism may directly inhibit Ferroptosis, which can induce apoptosis of granulosa cells, thereby regulating SYFs development in chickens. These findings could serve as a reference for improving the egg-laying performance of Tengchong snow chickens.

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