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Ontogeny and function of the intestinal epithelial and innate immune cells during early development of chicks: to explore in ovo immunomodulatory nutrition

文献类型： 外文期刊

作者： Ayalew, Habtamu 1 ; Xu, Changchun 1 ; Adane, Assefa 2 ; Sanchez, Astrid Lissette Barreto 1 ; Li, Siman 1 ; Wang, Jing 1 ; Wu, Shugeng 1 ; Qiu, Kai 1 ; Qi, Guanghai 1 ; Zhang, Haijun 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Feed Res, Lab Qual & Safety Risk Assessment Anim Prod Feed H, Minist Agr & Rural Affairs, Beijing 100081, Peoples R China

2.Univ Gondar, Coll Vet Med & Anim Sci, PoB 196, Gondar, Ethiopia

关键词： Chick; Innate immunity cell; Intestinal epithelial cell; In ovo nutrition; Development

期刊名称：POULTRY SCIENCE （ 影响因子：4.2； 五年影响因子：4.5 ）

ISSN： 0032-5791

年卷期： 2025 年 104 卷 1 期

页码：

收录情况： SCI

摘要： Intestinal epithelial cells (IECs) and innate immune cells in the gastrointestinal tract (GIT) of chickens play crucial roles in pathogens defense and maintaining gut health. However, their effectiveness influenced with their developmental and functional stages during pre and post hatch periods of chick. During embryonic development, differentiation and migration of these innate immune systems are tightly regulated by diverse cellular and molecular factors. The maturation and functionality of IECs are histologically evident starting embryonic day (ED) 14. Moreover, the innate immun cells, such as dendritic cells (DCs), macrophages, natural killer (NK) cells, and gamma-delta (gamma delta) T cells have showed developmental expression varation, while most identified by the 3rd days of incubation and capable of responsing to their cognate ligands of pathogens by ED 17, it may not efficient during posthatch period. In modern poultry production, in ovo feeding of bioactive substances is a topic of interest to maximize the protection capability of hatched chicks by enhancing improvement on the development of innate immune systems. However, their actions and effects on each distinct innate immune involved response are inconsistent and not clearly understood. Thus, summarizing the ontogeny and function of IECs, innate immunity systems, and interaction mechanisms of in ovo feeding of bioactive substances could provide baseline information for designing targeted in ovo feeding interventions to modulate cell waise specific innate immune systems.

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