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Distribution and transmission of fi-lactamase resistance genes in meal-to-milk chain on dairy farm

文献类型： 外文期刊

作者： Qi, Zheng 1 ; Jin, Shuhan 1 ; Guo, Xiaorui 1 ; Tong, Hailong 2 ; Ren, Nanqi 3 ; You, Shijie 3 ;

作者机构： 1.Harbin Univ Commerce, Engn Res Ctr Med, Minist Educ, Harbin 150076, Peoples R China

2.Harbin Vet Res Inst, Chinese Acad Agr Sci, State Key Lab Vet Biotechnol, Harbin 150069, Peoples R China

3.Harbin Inst Technol, Sch Environm, State Key Lab Urban Water Resource & Environm, Harbin 150090, Peoples R China

4.POB 2603,73 Huanghe Rd, Harbin 150090, Peoples R China

关键词： Antibiotic resistance genes; fi-lactamase resistance genes; Mobile genetic elements; Meal-to-milk chain

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.9； 五年影响因子：9.5 ）

ISSN： 0269-7491

年卷期： 2023 年 331 卷

页码：

收录情况： SCI

摘要： Antibiotics have been widely used in animal husbandry, which leads to high risk of food-borne transfer of antibiotic resistance genes (ARGs). The present study investigated the distribution of fi-lactamase resistance genes (fi-RGs) on dairy farm in the Songnen Plain of western Heilongjiang Province, China, to provide mecha-nistic insights into food-borne transmission of fi-RGs through "meal-to-milk" chain under practically relevant circumstances. The results demonstrated that the abundance of fi-RGs (91%) was much higher than that of other ARGs in the livestock farms. The blaTEM exhibited the content as high as 94.55% among all ARGs, and higher than 98% blaTEM was detected in meal, water and milk sample. The metagenomic taxonomy analysis indicated that the blaTEM should be carried by tnpA-04 (7.04%) and tnpA-03 (1.48%) hosted in Pseudomonas genus (15.36%) and Pantoea (29.02%) genus. Both tnpA-04 and tnpA-03 in the milk sample were identified to be the key mobile genetic elements (MGEs) responsible for transferring blaTEM along the "meal-manure-soil-surface water-milk" chain. The ARGs transfer across ecological boundaries underscored the need to evaluate potential dissemination of high-risk Proteobacteria and Bacteroidetes carried by humans and animals. They were capable of producing expanded-spectrum fi-lactamases (ESBLs) and destroying commonly used antibiotics, leading to possible risk of food-borne horizontal transmission of ARGs. This study not only has important environmental implications for identifying the pathway for ARGs transfer, but also highlights the demand for appropriate policy toward safe regulation of dairy farm and husbandry products.

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