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The goblet cells in lepidoptera intestines possess a plant-vacuole-like organelle for ethanol detoxification

文献类型： 外文期刊

作者： Huang, Wuren 1 ; Guan, Ruobing 2 ; Yang, Bing 3 ; Liu, Qiuning 4 ; Wu, Kai 5 ; Wang, Jing 5 ; Li, Muwang 6 ; Miao, Xue-Xia 1 ; Beerntsen, Brenda T. 7 ; Cui, Hongjuan 8 ; Pan, Guoqing 8 ; Ling, Erjun 1 ;

作者机构： 1.Chinese Acad Sci, Inst Plant Physiol & Ecol, Key Lab Plant Design, Shanghai 200036, Peoples R China

2.Henan Agr Univ, Coll Plant Protect, Zhengzhou 450002, Peoples R China

3.Shanghai Majorbio Biopharm Technol Co Ltd, Shanghai 201318, Peoples R China

4.Yancheng Teachers Univ, Sch Wetlands, Yancheng 224007, Peoples R China

5.Shangrao Normal Univ, Coll Life Sci, Shangrao 334001, Peoples R China

6.Chinese Acad Agr Sci, Sericultural Res Inst, Zhenjiang 212003, Jiangsu, Peoples R China

7.Univ Missouri, Vet Pathobiol, Columbia, MO 65211 USA

8.Southwest Univ, State Key Lab Resource Insects, Chongqing 400716, Peoples R China

关键词： Lepidopteran; midgut; organelle; gobletsome; proteomics

期刊名称：ENTOMOLOGIA GENERALIS （ 影响因子：4.6； 五年影响因子：4.4 ）

ISSN： 0171-8177

年卷期： 2025 年 45 卷 2 期

页码：

收录情况： SCI

摘要： Goblet cells, with their distinctive goblet-shaped structures, are found in the intestines of both humans and lepidopterans. In humans, these cells play a crucial role in defending against infections. However, our understanding of lepidopteran goblet cells is currently limited to their involvement in ion regulation. In this study, we have made a groundbreaking discovery that lepidopteran goblet cells contain an organelle called "gobletsome," which shows remarkable morphological similarities to plant vacuoles. Through proteomics analysis on purified gobletsomes, we have identified 404 proteins associated with diverse functions within this organelle, including ion regulation. Notably, alcohol dehydrogenase (ADH), one of these proteins, is exclusively found in the gobletsomes of various species of lepidopteran larvae; thus, serving as a distinctive marker for identifying goblet cells. Importantly, inhibiting ADH activity negatively affects food consumption and larval growth, highlighting the pivotal role played by lepidopteran goblet cells in ethanol detoxification within the intestines. The proteomics profiles of lepidopteran gobletsomes may serve as a valuable model for understanding their human counterparts.

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