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Aspirin Eugenol Ester Modulates the Hypothalamus Transcriptome in Broilers Under High Stocking Density

文献类型： 外文期刊

作者： Zhao, Xiaodie 1 ; Zhang, Yi 1 ; Bai, Dongying 1 ; Zhen, Wenrui 1 ; Guo, Caifang 1 ; Wang, Ziwei 1 ; Ma, Penghui 1 ; Ma, Xiqiang 3 ; Xie, Xiaolin 3 ; Ito, Koichi 4 ; Zhang, Bingkun 5 ; Yang, Yajun 6 ; Li, Jianyong 6 ; Ma, Yanbo 1 ;

作者机构： 1.Henan Univ Sci & Technol, Coll Anim Sci & Technol, Dept Anim Physiol, Luoyang 471003, Peoples R China

2.Henan Univ Sci & Technol, Coll Anim Sci & Technol, Henan Int Joint Lab Anim Welf & Hlth Breeding, Luoyang 471023, Peoples R China

3.Longmen Lab, Sci & Technol Innovat Ctr Completed Set Equipment, Innovat Res Team Livestock Intelligent Breeding &, Luoyang 471023, Peoples R China

4.Univ Tokyo, Grad Sch Agr & Life Sci, Dept Food & Physiol Models, Ibaraki 3190206, Japan

5.China Agr Univ, Coll Anim Sci & Technol, Dept Anim Nutr & Feed Sci, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

6.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Gansu Prov Key Lab Vet Pharmaceut Dev, Minist Agr & Rural Affairs,Key Lab New Anim Drug, Lanzhou 730050, Peoples R China

关键词： high stocking density; broiler; aspirin eugenol ester; hypothalamus; RNA-seq; transcriptome

期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2025 年 15 卷 6 期

页码：

收录情况： SCI

摘要： Broilers grown in a high-density (HD) stocking environment may experience intense competition that may adversely affect their growth relative to animals reared at a normal density (ND). The growth performance of HD broilers is increased by aspirin eugenol ester (AEE), although the mechanism by which this compound modulates hypothalamus-regulated feeding behavior is unclear. The aims of this study were to determine the effects of including AEE in the basal diet on the hypothalamic transcriptome and to examine in parallel the impact of these modifications on broiler production performance in HD conditions. Three hundred sixty one-day-old male Arbor Acres broilers were randomly divided into four groups: an ND group (14 broilers/m(2)), HD group (22 broilers/m(2)), ND-AEE group, and HD-AEE group. Each treatment group had 10 replicates, with 7 broilers per replicate in the ND and ND-AEE groups and 11 broilers per replicate in the HD and HD-AEE groups. Broiler growth performance was monitored, and hypothalamus samples were collected for transcriptome analysis on day 28. The HD group exhibited a reduced body weight (p < 0.01) at this timepoint compared to the ND group. However, the addition of AEE significantly improved average daily feed intake, average daily gain, and feed conversion ratio in the HD group from days 22 to 28 compared to the HD group without AEE (p < 0.05). The transcriptome results showed that 20 signaling pathways were commonly enriched among the groups (ND vs. HD, HD vs. HD-AEE). Several potential candidate genes were identified as involved in chicken central nervous system development and regulation of feed intake. Thus, the current study provides new insights into hypothalamic transcription patterns that are associated with the ameliorative effects of AEE in HD broilers.

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