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Anti-Inflammatory, Antipyretic, and Analgesic Potential of Chitin and Chitosan Derived from Cockroaches (Periplaneta americana) and Termites

文献类型： 外文期刊

作者： Asad, Khushbakht 1 ; Shams, Sumaira 1 ; Ibanez-Arancibia, Eliana 2 ; de los Rios-escalante, Patricio R. 4 ; Badshah, Farhad 1 ; Ahmad, Farooq 1 ; Khan, Muhammad Salman 1 ; Khan, Asar 1 ;

作者机构： 1.Abdul Wali Khan Univ Mardan, Dept Zool, Mardan 23200, Pakistan

2.Univ La Frontera, PhD Program Sci Mentioning Appl Mol & Cell Biol, Temuco 4780000, Chile

3.Univ La Frontera, Fac Engn & Sci, Dept Chem Engn, Lab Engn Biotechnol & Appl Biochem LIBBA, Temuco 4780000, Chile

4.Catholic Univ Temuco, Fac Nat Resources, Dept Biol & Chem Sci, Temuco 4780000, Chile

5.Catholic Univ Temuco, Fac Nat Resources, Nucleus Environm Studies, Temuco 4780000, Chile

6.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Biotech Breeding, Beijing 100193, Peoples R China

关键词： Periplaneta americana; biopolymers; chitosan; chitin; antipyretic; demineralization; deproteinization

期刊名称：JOURNAL OF FUNCTIONAL BIOMATERIALS （ 影响因子：4.8； 五年影响因子：5.9 ）

ISSN：

年卷期： 2024 年 15 卷 3 期

页码：

收录情况： SCI

摘要： The chitin and chitosan biopolymers are extremely valuable because of their numerous industrial and pharmacological uses. Chitin and chitosan were extracted from the exoskeleton of Periplaneta americana (cockroaches) and termites using various acid and alkali techniques. The extraction process involves an initial demineralization step, during which integument dry powder was subjected to 500 mL (2.07 mol/L) of concentrated HCl at 100 degrees Celsius for 30 min, followed by meticulous rinsing with distilled water to restore the pH to its baseline. Deproteinization was conducted at 80 degrees Celsius using 500 mL (1 mol/L) of NaOH solution, which was repeated for 24 h. A total of 250 mL (0.06 mol/L) of NaOH was added at 100 degrees Celsius for 4 h to obtain chitosan, followed by extensive washing and subsequent drying. FTIR analysis was used to identify the functional groups in Periplaneta americana and termites. The crystallinity of these biopolymers, which have a face-centered cubic structure, was determined by X-ray diffraction analysis. This study assessed the analgesic properties of chitin and chitosan via an acetic-acid-induced writhing test in mice, revealing a significant reduction in writhing behavior following the chitin and chitosan extract. Notably, chitin exhibits the highest degree of analgesic activity compared to chitosan. Both chitin and chitosan show anti-inflammatory effects, with chitosan absorbing proton ions at sites of inflammation, while chitin effectively inhibits ear edema and elicits an analgesic response in mice. Furthermore, the present study revealed antipyretic activity, with termite chitin demonstrating the most significant effect at a concentration of 500 mu L/mL, followed by chitosan and chitin at 100 mu L/mL. These findings indicate the potential of using chitin and chitosan derived from termites and Periplaneta americana as natural anti-inflammatory compounds, implying prospective uses in anti-inflammatory, antipyretic, and analgesic capabilities.

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