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Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies

文献类型： 外文期刊

作者： Elfadadny, Ahmed 1 ; Ragab, Rokaia F. 1 ; AlHarbi, Maha 4 ; Badshah, Farhad 5 ; Ibanez-Arancibia, Eliana 6 ; Farag, Ahmed 9 ; Hendawy, Amin Omar 10 ; De los Rios-Escalante, Patricio R. 8 ; Aboubakr, Mohamed 12 ; Zakai, Shadi A. 13 ; Nageeb, Wedad M. 14 ;

作者机构： 1.Tokyo Univ Agr & Technol, Cooperat Div Vet Sci, Lab Internal Med, Fuchu, Japan

2.Damanhour Univ, Fac Vet Med, Dept Internal Med, Damanhour, Egypt

3.Damanhour Univ, Fac Vet Med, Dept Biochem, Damanhour, Egypt

4.Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Biol, Riyadh, Saudi Arabia

5.Inst Anim Sci, Chinese Acad Agr Sci, State Key Lab Anim Biotech Breeding, Beijing, Peoples R China

6.Univ La Frontera, PhD Program Sci Mentioning Appl Mol & Cell Biol, Temuco, Chile

7.Univ La Frontera, Fac Engn & Sci, Dept Chem Engn, Lab Engn Biotechnol & Appl Biochem LIBBA, Temuco, Chile

8.Catholic Univ Temuco, Fac Nat Resources, Dept Biol & Chem Sci, Temuco, Chile

9.Zagazig Univ, Fac Vet Med, Dept Surg Anesthesiol & Radiol, Zagazig, Egypt

10.Damanhour Univ, Fac Agr, Dept Anim & Poultry Prod, Damanhour, Egypt

11.Catholic Univ Temuco, Fac Nat Resources, Nucleus Environm Studies, Temuco, Chile

12.Benha Univ, Fac Vet Med, Dept Pharmacol, Toukh, Qaliobiya, Egypt

13.King Abdulaziz Univ, Fac Med, Dept Clin Microbiol & Immunol, Jeddah, Saudi Arabia

14.Suez Canal Univ, Fac Med, Dept Med Microbiol & Immunol, Ismailia, Egypt

关键词： Pseudomonas aeruginosa; resistance; pathogenicity; virulence; therapy

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）

ISSN：

年卷期： 2024 年 15 卷

页码：

收录情况： SCI

摘要： Pseudomonas aeruginosa, a Gram-negative bacterium, is recognized for its adaptability and opportunistic nature. It poses a substantial challenge in clinical settings due to its complicated antibiotic resistance mechanisms, biofilm formation, and capacity for persistent infections in both animal and human hosts. Recent studies revealed a potential zoonotic transmission of P. aeruginosa between animals, the environment, and human populations which highlights awareness of this microbe. Implementation of the One Health approach, which underscores the connection between human, animal, and environmental health, we aim to offer a comprehensive perspective on the current landscape of P. aeruginosa management. This review presents innovative strategies designed to counteract P. aeruginosa infections. Traditional antibiotics, while effective in many cases, are increasingly compromised by the development of multidrug-resistant strains. Non-antibiotic avenues, such as quorum sensing inhibition, phage therapy, and nanoparticle-based treatments, are emerging as promising alternatives. However, their clinical application encounters obstacles like cost, side effects, and safety concerns. Effectively addressing P. aeruginosa infections necessitates persistent research efforts, advancements in clinical development, and a comprehension of host-pathogen interactions to deal with this resilient pathogen.

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