Facile One-Pot Assembly of a Versatile Photoactive Nanozyme for Highly Efficient Antibacterial Therapy
文献类型： 外文期刊
作者： Chen, Yingying 1 ; Ma, Kang 1 ; Liang, Meijuan 1 ; Dong, Pei 1 ; Wang, Hong 1 ; Yu, Shanshan 1 ; Sun, Jianwei 2 ; Kwok, Ryan T. K. 2 ; Lam, Jacky W. Y. 2 ; Gao, Yuhui 5 ; Tang, Ben Zhong 2 ; Wang, Fuan 1 ;
作者机构： 1.Wuhan Univ, Zhongnan Hosp, Coll Chem & Mol Sci, Dept Gastroenterol, Wuhan 430071, Peoples R China
2.Hong Kong Univ Sci & Technol, Hong Kong Branch Chinese Natl Engn Res Ctr Tissue, Dept Chem, Kowloon,Dept Chem & Biol Engn,State Key Lab Mol Ne, Clear Water Bay, Hong Kong 999077, Peoples R China
3.Hong Kong Univ Sci & Technol, Div Life Sci, Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China
4.Chinese Acad Agr Sci, Oil Crops Res Inst, Wuhan 430062, Peoples R China
5.Fujian Tobacco Qual Supervis & Test Stn, Fuzhou 350003, Peoples R China
6.Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen CUHK, Shenzhen 518172, Guangdong, Peoples R China
7.Wuhan Univ, Res Inst Shenzhen, Shenzhen 518057, Peoples R China
关键词： biofilms; catalytic therapy; diabetic infections; nanozyme; photodynamic therapy
期刊名称：SMALL （ 影响因子：12.1； 五年影响因子：12.5 ）
ISSN： 1613-6810
年卷期： 2025 年 21 卷 16 期
页码：
收录情况： SCI
摘要： Conventional combinational antibacterial therapy requires the complicated assembly of multiple components that might cause a premature leak of therapeutic agents. Thus the one-pot assembly of highly integrated multifunctional antibacterial agents is highly desirable for treating multidrug-resistant (MDR) bacteria. Herein, the vancomycin-derived carbon dots (Van-CDs) are facilely developed as a compact and powerful multifunctional photodynamic nanozyme platform that achieves the augmented reactive oxygen species (ROS) generation for accelerating bacterial elimination. By residual recognition groups of vancomycin, the red emissive Van-CDs gain a specific affinity toward bacteria with a high binding constant of 20 L g-1, manifesting a superior bacteria-imaging ability. Meanwhile, Van-CDs are encoded with an excellent peroxidase-mimicking (POD) activity for mediating the H2O2-activated evolvement of center dot OH, and also endowed with intrinsic photodynamic property for simultaneously producing singlet oxygen (1O2). Surprisingly, the photodynamic Van-CDs nanozyme possesses an auxiliary photothermal feature, which enables the photothermal imaging-guided hyperthermia-reinforced antibacterial therapy in vivo. Furthermore, a subcutaneous abscess model is established to validate their pronounced biofilm eradication and wound healing acceleration in vivo through the Van-CDs-promoted collagen deposition. Taken together, the present all-in-one compact photodynamic carbon-derived nanozyme with multiple intrinsic therapeutic functions represents a promising and competitive candidate for treating diabetic infections of clinical research.
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