NIR/pH-responsive arginine-ε-polylysine/black phosphorus nanocomposites for synergistic therapy of bacterial infections
文献类型： 外文期刊
作者： Gao, Qian 1 ; Fu, Ranran 1 ; Li, Mengting 3 ; Guo, Dongbo 1 ; Gan, Bingcheng 2 ; Wang, Tao 2 ; Chen, Maohua 1 ;
作者机构： 1.Hainan Univ, Sanya Res Inst, Sch Biomed Engn, Lab Digital Med Engn, Sanya 572025, Peoples R China
2.Chinese Acad Agr Sci, Chengdu Natl Agr Sci & Technol Ctr, Inst Urban Agr, Chengdu 610213, Peoples R China
3.Hainan Univ, Hainan Prov Fine Chem Engn Res Ctr, Sch Chem Engn & Technol, Haikou 570228, Peoples R China
关键词： Nitric oxide gas therapy; Photodynamic therapy; Black phosphorus nanosheets; epsilon-Polylysine; Synergistic antibacterial effect
期刊名称：MATERIALS TODAY BIO （ 影响因子：10.2； 五年影响因子：10.2 ）
ISSN： 2590-0064
年卷期： 2025 年 34 卷
页码：
收录情况： SCI
摘要： The escalating global burden of drug-resistant bacterial infections demands urgent innovation in highly effective, non-invasive antimicrobial strategies. Herein, we developed a multimodal near infrared (NIR) light-responsive bactericidal nanoplatform (BP@EPL-LA) with surface charge adaptability by loading black phosphorus nanosheets with L-Arg-grafted epsilon-poly(L-lysine) for targeted combinatorial therapy of subcutaneous abscesses. Under physiological conditions, BP@EPL-LA remained a neutral surface charge and demonstrated excellent biosafety both in vitro and in vivo. Upon encountering the acidic infectious environment, BP@EPL-LA rapidly switched to a positive surface charge, promoting deep biofilm penetration and strong electrostatic adhesion to negatively charged bacterial membranes. When irradiated by 660 nm laser, BP@EPL-LA mediated antibacterial photodynamic therapy (aPDT), generating reactive oxygen species (ROS) that oxidized arginine residues to enable controlled nitric oxide (NO) release. BP@EPL-LA effectively dispersed bacterial biofilms and demonstrated broad-spectrum antibacterial activity through the synergistic combination of ROS, NO, and EPL. Moreover, BP@EPL-LA showed remarkable therapeutic outcomes in a mouse model of subcutaneous Methicillin-resistant Staphylococcus aureus abscesses, simultaneously eradicating bacterial infection, reducing inflammation, and promoting tissue healing via enhanced vascularization and collagen deposition. Therefore, BP@EPL-LA overcomes antibiotic resistance barriers and presents a promising therapeutic strategy for effective subcutaneous abscess treatment by integrating NO-potentiated aPDT with EPL's bactericidal action.
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