Expression Profile of Porcine TRIM26 and Its Inhibitory Effect on Interferon-beta Production and Antiviral Response
文献类型： 外文期刊
作者： Huang, Hui 1 ; Sharma, Mona 1 ; Zhang, Yanbing 1 ; Li, Chenxi 1 ; Liu, Ke 1 ; Wei, Jianchao 1 ; Shao, Donghua 1 ; Li, Bei 1 ;
作者机构： 1.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China
2.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China
关键词： TRIM26; antiviral response; IFN-β poly (I; C); VSV; PRRSV
期刊名称：GENES （ 影响因子：4.096； 五年影响因子：4.339 ）
ISSN：
年卷期： 2020 年 11 卷 10 期
页码：
收录情况： SCI
摘要： TRIM26, a member of the tripartite motif (TRIM) family has been shown to be involved in modulation of innate antiviral response. However, the functional characteristics of porcine TRIM26 (porTRIM26) are unclear. In this study, we used a synthesized antigen peptide to generate a polyclonal antibody against porTRIM26 with which to study the expression and function of porTRIM26. We demonstrated that polyinosinic:polycytidylic acid (poly (I:C)) stimulation and viral infection (vesicular stomatitis (VSV) or porcine reproductive and respiratory syndrome virus (PRRSV)) induce expression of porTRIM26, whereas knock-down expression of porTRIM26 promotes interferon (IFN)-beta production after poly (I:C) stimulation and virus infection (VSV or PRRSV). The importance of the porTRIM26-mediated modulation of the antiviral response was also shown in VSV- or PRRSV-infected cells. In summary, these findings show that porTRIM26 has an inhibitory role in IFN-beta expression and the antiviral response.
- 相关文献
作者其他论文 更多>>
-
An Overview of Zika Virus and Zika Virus Induced Neuropathies
作者：Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Mustafa, Bahar E.;Mustafa, Bahar E.;Tawaab, Abdul;Hameed, Muddassar;Hameed, Muddassar;Hameed, Muddassar;Batool, Hira;Shoaib, Anam;Wei, Jianchao
关键词：neurotropic flaviviruses; zika virus; neuropathies; transmission; neuropathogenesis; prevention; vaccines; treatment; antivirals; mosquito/vector control; oncolytic; animal and cell models
-
A compendium of 8,176 bat RNA viral metagenomes reveals ecological drivers and circulation dynamics
作者：Yan, Xiaomin;Liu, Yang;Li, Chenxi;Liu, Yuhang;Li, Nan;Sun, Yue;Yi, Le;Tu, Changchun;He, Biao;Hu, Tingsong;Zhang, Fuqiang;Huang, Zhenglanyi;Feng, Jiang;Jiang, Tinglei;Guo, Lei;Zhang, Hailin;Wu, Jianmin;Tu, Changchun
关键词：
-
GhADT5 enhances alkali stress tolerance in cotton by regulating phenylalanine-derived flavonoid biosynthesis and antioxidant defense
作者：Wang, Lidong;Zhang, Menghao;Meng, Junting;Liu, Mengyue;Meng, Yuan;Chen, Wenhua;Fan, Yapeng;Huang, Hui;Sun, Yuping;Yang, Zhining;Chen, Xiao;Wu, Fange;Song, Ruize;Wang, Shuai;Lu, Xuke;Chen, Xiugui;Zhao, Lanjie;Wang, Junjuan;Cui, Yupeng;Ye, Wuwei;Wang, Lidong;Chen, Qin;Ye, Wuwei;Nan, Hongyu;Wang, Ning;Feng, Keyun;Guang, Lijun;Zhou, Xue-Rong
关键词：Phenylalanine (phe); Flavonoid biosynthesis; Arogenate dehydratase (ADT);
GhADT5 ; Cotton (Gossypium Spp. ); Virus-induced gene silencing (VIGS); Cotton breeding -
Development of a Noninfectious Japanese Encephalitis Virus Replicon for Antiviral Drug Screening and Gene Function Studies
作者：Yang, Yang;Zheng, Jiayang;Lin, Yafang;Zhang, Hailong;Zhang, Junjie;Li, Zongjie;Liu, Ke;Li, Beibei;Shao, Donghua;Qiu, Yafeng;Ma, Zhiyong;Wei, Jianchao;Zhang, Yan;Zhao, Qianming
关键词：Japanese encephalitis virus; replicon; green fluorescent protein; antiviral drug screening; RNA replication
-
Sheep serve as amplifying hosts of Japanese encephalitis virus, increasing the risk of human infection
作者：Zhang, Hailong;Li, Dan;Zheng, Jiayang;Qiu, Yafeng;Liu, Ke;Li, Zongjie;Li, Beibei;Shao, Donghua;Ma, Zhiyong;Wei, Jianchao;Zhang, Hailong;Liu, Juxiang;Bao, Jingyue;Wang, Zhiliang
关键词：
-
Lambda exonuclease assisted helicase-dependent amplification CRISPR/Cas12a detection of Listeria monocytogenes
作者：Wang, Chen;Wang, Qingshuang;Jin, Yushi;Xin, Meiyan;Jiang, Xue;Wang, Chen;Li, Chenxi;Wan, Jiayu;Li, Chenxi
关键词：Helicase; Isothermal amplification; CRISPR/Cas12; Listeria monocytogenes detection
-
Partial protective efficacy of the current licensed Japanese encephalitis live vaccine against the emerging genotype I Japanese encephalitis virus isolated from sheep
作者：Zhang, Hailong;Liu, Juxiang;Zhang, Yan;Li, Dan;Zheng, Jiayang;Zhang, Junjie;Li, Zongjie;Liu, Ke;Li, Beibei;Shao, Donghua;Qiu, Yafeng;Ma, Zhiyong;Wei, Jianchao
关键词：Japanese encephalitis virus; sheep; SA14-14-2 vaccine; neutralizing antibodies; protective efficacy
