Distribution and association study ofPLAG1gene between copy number variation and Chinese cattle populations
文献类型: 外文期刊
作者: Zhang, Zijing 1 ; Yang, Peng 2 ; He, Pan 2 ; Xu, Jiawei 2 ; Lyu, Shijie 1 ; Liu, Xian 3 ; Cai, Cuicui 4 ; Li, Huimin 5 ; Li, 1 ;
作者机构: 1.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou, Henan, Peoples R China
2.Northwest A&F Univ, Coll Anim Sci & Technol, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China
3.Henan Prov Anim Husb Gen Stn, Zhengzhou, Henan, Peoples R China
4.Ningxia Acad Agr & Forestry Sci, Guyuan Branch, Guyuan, Ningxia, Peoples R China
5.Agr & Rural Work Comm Huiji Dist, Zhengzhou, Peoples R China
关键词: Copy number variations; Cattle; PLAG1 gene; Association; Distribution
期刊名称:ANIMAL BIOTECHNOLOGY ( 影响因子:2.282; 五年影响因子:1.702 )
ISSN: 1049-5398
年卷期:
页码:
收录情况: SCI
摘要: Copy number variation mainly refers to the copy number change of DNA fragments from 1 to 5 Mb. The deletion, duplication, inversion and ectopic of these fragments are collectively referred to as CNV. Numerous studies have shown that transfer factors play a vital role in regulating the growth and development of the body, for example the pleomorphic adenoma gene (PLAG). However, there is no study of CNV inPLAG1gene. We qualified copy numbers withinPLAG1gene in 8 cattle breeds (Qinchuan, Qaidamu, Jinjiang, Guangfeng, Ji'an, Jiaxian, Pinan and Xianan cattle) by quantitative PCR, and explored their impacts on CNV ofPLAG1gene and phenotypic traits in Xianan cattle. We defined Deletion into CN = 0, Normal into CN = 1 and Duplication into CN = 2. The results showed that the individual with type of CN = 1 has a significant better effect on heart girth in JA cattle population (p < 0.01); the individual with type of CN = 1 and CN = 0 has a better effect on Rump length in JX cattle population (p < 0.05); the individual with type of CN = 0 has a better effect on cannon bone circumference in XN cattle population (p < 0.05). Association analysis showed that in JA cattle, the number of CN = 2 is great in JA cattle population, and the performance of CN = 2 in heart girth is better than CN = 1; in JX cattle, the rump length of CN = 2 is less than individual with CN = 0 and CN = 1; in XN cattle, individuals with CN = 0 have a better performance on cannon bone circumference than others. The results can provide a theoretical basis for molecular breeding of Chinese cattle, molecular mark-assist selection (MAS) of growth traits of Chinese cattle, and rapidly establish a Chinese cattle population with excellent genetic resources. Simple summary With the living standards rising, people's demand for beef is getting higher and higher, and there is a great significance to improve the growth performance of cattle. We measured body size data and detected copy number type of different cattle breeds (Xianan cattle, Ji'an cattle and Jiaxian cattle), and analyzed the correlation between the two object. We found that copy number variation ofPLAG1gene significantly affected some growth traits of XN cattle, JA cattle, and JX cattle. This may provide the basic material for molecular marker-assisted selection breeding of Chinese cattle breeds.
- 相关文献
作者其他论文 更多>>
-
High-density genotyping reveals candidate genomic regions for chicken body size in breeds of Asian origin
作者:Lyu, Shijie;Arends, Danny;Brockmann, Gudrun A.;Lyu, Shijie;Wang, Eryao;Arends, Danny;Nassar, Mostafa K.;Weigend, Annett;Weigend, Steffen
关键词:Asian Game type chicken; Asian Bantam type chicken; growth; GWAS; PCA
-
The relationship between MUC19 copy number variation and growth traits of Chinese cattle
作者:Chen, Yihe;Zhang, Jun;Huang, Yongzhen;Peng, Wei;Fu, Changqi;Zhang, Jun;Zhang, Zijing;Wang, Eryao;Liu, Xian;Wang, Hongli;Zhou, Sensen;Huang, Yongzhen
关键词:Cattle; Copy number variations; MUC19 gene; Association analysis
-
Bta-miR-200b promotes endometrial epithelial cell apoptosis by targeting MYB in cattle
作者:Lyu, Shijie;Zhai, Yaying;Zhu, Xiaoting;Shi, Qiaoting;Chen, Fuying;Zhang, Geyang;Zhang, Zijing;Wang, Eryao;Zhai, Yaying;Zhang, Geyang
关键词:Bovine; miR-200b; Endometrial receptivity; Apoptosis; Proliferation
-
A Chinese indicine pangenome reveals a wealth of novel structural variants introgressed from other Bos species
作者:Dai, Xuelei;Bian, Peipei;Hu, Dexiang;Luo, Funong;Huang, Yongzhen;Jiao, Shaohua;Wang, Xihong;Gong, Mian;Li, Ran;Cai, Yudong;Wen, Jiayue;Yang, Qimeng;Nanaei, Hojjat Asadollahpour;Wang, Yu;Wang, Fei;Jiang, Yu;Deng, Weidong;Nanaei, Hojjat Asadollahpour;Zhang, Zijing;Rosen, Benjamin D.;Heller, Rasmus;Jiang, Yu
关键词:
-
Genetic diversity and signatures of selection in BoHuai goat revealed by whole-genome sequencing
作者:Yao, Zhi;Zhang, Shunjin;Guo, Yingwei;Jiang, Yu;Huang, Yongzhen;Wang, Xianwei;Xu, Zejun;Xin, Xiaoling;Zhang, Zijing;Wang, Eryao
关键词:BoHuai goat; WGS; Genetic diversity; Population structure; Selection
-
Copy number variation of the ZNF679 gene in cattle and its association analysis with growth traits
作者:Song, Xingya;Li, Xinmiao;Ding, Xiaoting;Lei, Chuzhao;Chen, Hong;Huang, Yongzhen;Li, Xinmiao;Liu, Wujun;Liu, Xian;Li, Zhiming;Ru, Baorui;Zhang, Zijing;Chai, Yanan;Chen, Fuying;Shi, Qiaoting;Wang, Eryao;Wang, Hongli;Li, Jungang;Liang, Huifeng;Sun, Xiaoyan;Yang, Guojie;Qi, Zengfang;Huang, Yongzhen;Liu, Wujun
关键词:ZNF679; Copy number variations (CNVs); Growth traits; Association; Bos taurus (cattle)
-
Identification and Functional Analysis of Transcriptome Profiles, Long Non-Coding RNAs, Single-Nucleotide Polymorphisms, and Alternative Splicing from the Oocyte to the Preimplantation Stage of Sheep by Single-Cell RNA Sequencing
作者:Zhang, Zijing;Shi, Qiaoting;Zhu, Xiaoting;Jin, Lei;Lang, Limin;Lyu, Shijie;Xin, Xiaoling;Xu, Zhaoxue;Wang, Eryao;Huang, Yongzhen;Yu, Xiang;Li, Zhiming;Chen, Sujuan;Zhang, Wei
关键词:transcriptome profiles; long non-coding RNAs; single-nucleotide polymorphisms; alternative splicing; sheep; preimplantation; single-cell RNA sequencing