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Jiawei Shengmai San herbal formula ameliorates diabetic associate cognitive decline by modulatingAKTandCREBin rats

文献类型： 外文期刊

作者： Ahmed, Ayaz 1 ; Zeng, Guirong 2 ; Azhar, Mudassar 1 ; Lin, Haiying 1 ; Zhang, Mijia 1 ; Wang, Fengzhong 6 ; Zhang, Hon 1 ;

作者机构： 1.Southwest Med Univ, Affiliated TCM Hosp, Sino Portugal TCM Int Cooperat Ctr, Sch Basic Med, Luzhou 646000, Peoples R China

2.Hunan Key Lab Pharmacodynam & Safety Evaluat New, Changsha, Peoples R China

3.Hunan Prov Res Ctr Safety Evaluat Drugs, Changsha, Peoples R China

4.Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi, Pakistan

5.Chinese Acad Med Sci & Peking Union Med Coll, Res Ctr Pharmacol & Toxicol, Inst Med Plant Dev IMPLAD, Beijing, Peoples R China

6.Chinese Acad Agr Sci CAAS, Inst Food Sci & Technol, Beijing, Peoples R China

7.Hamdard Univ, Hamdard Al Majeed Coll Eastern Med, Karachi, Pakistan

8.King Abdulaziz Univ, Coll Sci, Dept Biochem, Jeddah, Saudi Arabia

关键词： diabetes-associated cognitive decline; Morris water maze; protein kinase B (Akt) and cAMP response element binding protein (CREB); reference and working memory

期刊名称：PHYTOTHERAPY RESEARCH （ 影响因子：5.878； 五年影响因子：5.286 ）

ISSN： 0951-418X

年卷期：

页码：

收录情况： SCI

摘要： Memory loss is a complication of diabetes which requires new approaches to its treatment. Shengmai San (SMS) is a famous traditional Chinese formula containingPanax ginseng,Ophiopogon japonicas, andSchisandra chinensis, whereas Radix puerariae has many reported pharmacological uses. In this study the combination, as Jiawei SMS (J-SMS) was screened for its ability to reverse diabetes-associated cognitive decline in rats. This was assessed behaviorally in diabetic rats (Streptozotocin, 45 mg/kg), with biochemical and western blot analysis (Akt and CREB). Diabetic rats showed fasting blood glucose (FBG) in the range of 13-15 mM throughout the study. J-SMS (0.5, 1.5, 4.5 g/kg) treatment significantly improved learning and memory deficit among diabetic rats as evidenced by preference for novel object, reduced escape latency and increased number of platform crossings (p< .05) in the NORT and MWM tests. Treatment with J-SMS also significantly improved the histopathological changes in the diabetic brain and increased the protein expression of AKT and CREB, required for proper memory function (p< .01). This study highlighted that J-SMS can reverse reference and working memory deficit among diabetic rats by modulating AKT and CREB proteins activation. Thus, J-SMS formulation might be possible candidate for further development.

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