A live attenuated influenza B virus vaccine expressing RBD elicits protective immunity against SARS-CoV-2 in mice
文献类型： 外文期刊
作者： Wang, Zhenfei 1 ; Sun, Weiyang 1 ; Li, Dongxu 1 ; Sun, Yue 1 ; Zhu, Menghan 1 ; Wang, Wenqi 1 ; Zhang, Yiming 1 ; Li, Entao 1 ; Yan, Feihu 1 ; Wang, Tiecheng 1 ; Feng, Na 1 ; Yang, Songtao 1 ; Xia, Xianzhu 1 ; Gao, Yuwei 1 ;
作者机构： 1.Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun, Peoples R China
2.Jilin Agr Univ, Coll Anim Sci & Technol, Coll Vet & Med, Changchun, Peoples R China
3.Shanxi Agr Univ, Coll Vet Med, Jinzhong, Peoples R China
4.Northeast Normal Univ, Sch Life Sci, Jilin Prov Key Lab Chem & Biol Changbai Mt Nat Dru, Changchun, Peoples R China
5.Henan Univ, Sch Basic Med Sci, Henan Int Joint Lab Nucl Prot Regulat, Kaifeng, Peoples R China
6.Shandong Normal Univ, Coll Life Sci, Key Lab Anim Resistant Biol Shandong, Jinan, Peoples R China
关键词： SARS-CoV-2; Influenza virus -vector vaccine; Spike RBD; Intranasal vaccination; Mice
期刊名称：VIRUS RESEARCH （ 影响因子：5.0； 五年影响因子：4.0 ）
ISSN： 0168-1702
年卷期： 2024 年 345 卷
页码：
收录情况： SCI
摘要： Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant threat to human health globally. It is crucial to develop a vaccine to reduce the effect of the virus on public health, economy, and society and regulate the transmission of SARS-CoV-2. Influenza B virus (IBV) can be used as a vector that does not rely on the current circulating influenza A strains. In this study, we constructed an IBV-based vector vaccine by inserting a receptor -binding domain (RBD) into a non-structural protein 1 (NS1)-truncated gene (rIBV-NS110-RBD). Subsequently, we assessed its safety, immunogenicity, and protective efficacy against SARS-CoV-2 in mice, and observed that it was safe in a mouse model. Intranasal administration of a recombinant rIBV-NS110-RBD vaccine induced high levels of SARS-CoV-2-specific IgA and IgG antibodies and T cell -mediated immunity in mice. Administering two doses of the intranasal rIBV-NS110-RBD vaccine significantly reduced the viral load and lung damage in mice. This novel IBV-based vaccine offers a novel approach for controlling the SARS-CoV-2 pandemic.
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