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Variants in BMP15 Gene Affect Promoter Activity and Litter Size in Gobi Short Tail and Ujimqin Sheep

文献类型： 外文期刊

作者： Wang, Shenyuan 1 ; Bai, Yanyu 2 ; Wang, Daqing 3 ; Zhang, Ming 4 ; Alatan, Suhe 5 ; Cang, Ming 2 ; Jin, Hai 6 ; Li, Changqing 6 ; Du, Guangchen 3 ; Cao, Guifang 3 ; Tong, Bin 1 ;

作者机构： 1.Inner Mongolia Agr Univ, Coll Life Sci, Inner Mongolia Key Lab Biomanufacture, Hohhot 010020, Peoples R China

2.Inner Mongolia Univ, Sch Life Sci, State Key Lab Reprod Regulat & Breeding Grassland, Hohhot 010020, Peoples R China

3.Inner Mongolia Agr Univ, Coll Vet Med, Hohhot 010011, Peoples R China

4.Inner Mongolia Mengyuan Sheep Breeding Co, Baotou 014016, Peoples R China

5.East Ujimqin Hexig Anim Husb Dev Co, Xilingol 026399, Peoples R China

6.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010031, Peoples R China

关键词： BMP15; litter size; Gobi short tail sheep; Ujimqin sheep; promoter activity

期刊名称：VETERINARY SCIENCES （ 影响因子：2.3； 五年影响因子：2.4 ）

ISSN：

年卷期： 2025 年 12 卷 3 期

页码：

收录情况： SCI

摘要： Reproductive performance in sheep plays a crucial role in determining the economic efficiency of the industry, with increasing litter size being a key focus for genetic improvement. The BMP15 gene is widely recognized as a major gene influencing sheep fertility. In this study, specific mutations in the BMP15 gene of Gobi short tail sheep were identified through direct sequencing, and these mutations were genotyped using the MassARRAY system. The g.54285159_54285161TTA indel was significantly associated with litter size in Gobi short tail sheep (p < 0.05). Three mutations, including g.54291460G>A, g.54288671C>T, and the g.54285159_54285161TTA indel, were significantly associated with litter size in Ujimqin sheep (p < 0.05). Furthermore, the promoter activity analysis demonstrated that the A allele exhibited significantly higher promoter activity compared to the G allele of the g.54291460G>A mutation. These findings highlight valuable genetic markers for improving sheep litter size and provide a robust theoretical foundation for further research on the BMP15 gene's role in reproduction.

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