文献类型： 外文期刊

作者： Wang, Hongru ¹ ; Yang, Melinda A. ¹ ; Wangdue, Shargan ³ ; Lu, Hongliang ⁴ ; Chen, Honghai ⁶ ; Li, Linhui ³ ; Dong, Guanghui ⁷ ; Tsring, Tinley ³ ; Yuan, Haibing ⁴ ; He, Wei ³ ; Ding, Manyu ¹ ; Wu, Xiaohong ⁹ ; Li, Shuai ⁴ ; Tashi, Norbu ³ ; Yang, Tsho ³ ; Yang, Feng ⁴ ; Tong, Yan ³ ; Chen, Zujun ³ ; He, Yuanhong ⁴ ; Cao, Peng ¹ ; Dai, Qingyan ¹ ; Liu, Feng ¹ ; Feng, Xiaotian ¹ ; Wang, Tianyi ¹ ; Yang, Ruowei ¹ ; Ping, Wanjing ¹ ; Zhang, Zhaoxia ¹ ; Gao, Yang ¹⁰ ; Zhang, Ming ⁶ ; Wang, Xiaoji ¹¹ ; Zhang, Chao ¹¹ ; Yuan, Kai ¹¹ ; Ko, Albert Min-Shan ¹ ; Aldenderfer, Mark ¹² ; Gao, Xing ¹ ; Xu, Shuhua ¹⁰ ; Fu, Qiaomei ¹ ;

作者机构： 1.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Ctr Excellence Life & Paleoenvironm, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China

2.Univ Richmond, Dept Biol, Richmond, VA 23173 USA

3.Tibet Inst Conservat & Res Cultural Rel, Lhasa 850000, Peoples R China

4.Sichuan Univ, Sch Archaeol & Museol, Chengdu 610064, Peoples R China

5.Sichuan Univ, Ctr Archaeol Sci, Chengdu 610064, Peoples R China

6.Northwest Univ, Sch Cultural Heritage, Xian 710069, Peoples R China

7.Lanzhou Univ, Coll Earth & Environm Sci, Key Lab Western Chinas Environm Syst, Minist Educ, Lanzhou 730000, Peoples R China

8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

9.Peking Univ, Sch Archaeol & Museol, Beijing 100871, Peoples R China

10.Fudan Univ, Ctr Evolutionary Biol, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci,State Key Lab Genet Engn, Shanghai 200438, Peoples R China

11.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Key Lab Computat Biol, Shanghai 200031, Peoples R China

12.Univ Calif Merced, Dept Anthropol & Heritage Studies, Merced, CA 95343 USA

13.Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Dept Liver Surg & Transplantat, Shanghai 200032, Peoples R China

14.Fudan Univ, Human Phenome Inst, Zhangjiang Fudan Int Innovat Ctr, Shanghai 201203, Peoples R China

15.Fudan Univ, Key Lab Contemporary Anthropol, Minist Educ, Shanghai 201203, Peoples R China

16.Shanghai Qi Zhi Inst, Shanghai 200232, Peoples R China

17.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen 518120, Peoples R China

期刊名称：SCIENCE ADVANCES （ 影响因子：13.6； 五年影响因子：15.4 ）

ISSN： 2375-2548

年卷期： 2023 年 9 卷 11 期

页码：

收录情况： SCI

摘要： Using genome-wide data of 89 ancient individuals dated to 5100 to 100 years before the present (B.P.) from 29 sites across the Tibetan Plateau, we found plateau-specific ancestry across plateau populations, with substantial genetic structure indicating high differentiation before 2500 B.P. Northeastern plateau populations rapidly showed admixture associated with millet farmers by 4700 B.P. in the Gonghe Basin. High genetic similarity on the southern and southwestern plateau showed population expansion along the Yarlung Tsangpo River since 3400 years ago. Central and southeastern plateau populations revealed extensive genetic admixture within the plateau historically, with substantial ancestry related to that found in southern and southwestern plateau populations. Over the past similar to 700 years, substantial gene flow from lowland East Asia further shaped the genetic landscape of present-day plateau populations. The high-altitude adaptive EPAS1 allele was found in plateau populations as early as in a 5100-year-old individual and showed a sharp increase over the past 2800 years.