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Inhibitory effects and mechanisms of phenolic compounds in rapeseed oil on advanced glycation end product formation in chemical and cellular models in vitro

文献类型： 外文期刊

作者： Liu, Huihui 1 ; Zhang, Ruiying 2 ; Wang, Wen 1 ; Xia, Xiaoyang 1 ; Xu, Zhenxia 1 ; Xiang, Xia 1 ;

作者机构： 1.Chinese Acad Agr Sci, Oil Crops & Lipids Proc Technol Natl & Local Joint, Key Lab Oilseeds Proc,Minist Agr & Rural Affairs, Hubei Key Lab Lipid Chem & Nutr,Oil Crops Res Inst, Wuhan 430062, Peoples R China

2.Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China

关键词： Phenolic compounds; Rapeseed oil; Advanced glycation end products; Methylglyoxal; Lipid mediators

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2024 年 447 卷

页码：

收录情况： SCI

摘要： Sinapic acid (SA), canolol (CAO) and canolol dimer (CAO dimer) are the main phenolic compounds in rapeseed oil. However, their possible efficacy against glycation remains unclear. This study aims to explore the impacts of these substances on the formation of advanced glycation end products (AGEs) based on chemical and cellular models in vitro . Based on fluorescence spectroscopy results, three chemical models of BSA -fructose, BSA-methylglyoxal (MGO), and arginine (Arg)-MGO showed that SA/CAO/CAO dimer could effectively reduce AGE formation but with different abilities. After SA/CAO/CAO dimer incubation, effective protection against BSA protein glycation was observed and three different MGO adducts were formed. In MGO-induced HUVEC cell models, only CAO and CAO dimer significantly inhibited oxidative stress and cell apoptosis, accompanied by the regulation of the Nrf2-HO-1 pathway. During the inhibition, 20 and 12 lipid mediators were reversed in the CAO and CAO dimer groups compared to the MGO group.

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