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Chemical and physical characterization, stability and antioxidant activity of avicularin/(2-hydroxypropyl)-p-cyclodextrin inclusion complex

文献类型： 外文期刊

作者： Zhu, Xiaoai 1 ; Cao, Yong 2 ; Deng, Qianchun 3 ; Xiang, Xia 3 ; Xi, Jun 1 ; Feng, Konglong 2 ; Gao, Zili 4 ; Liu, Kunlun 1 ; Xiao, Hang 4 ;

作者机构： 1.Henan Univ Technol, Coll Food Sci & Engn, Food Engn Technol Res Ctr, Key Lab Henan Prov, Zhengzhou 450001, Peoples R China

2.South China Agr Univ, Coll Food Sci, Guangdong Prov Key Lab Nutraceut & Funct Foods, Guangzhou 510642, Peoples R China

3.Chinese Acad Agr Sci, Minist Agr & Rural Affairs, Key Lab Biol & Genet Improvement Oil Crops, Key Lab Oilseeds Proc,Oil Crops Res Inst, Wuhan 430062, Peoples R China

4.Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA

关键词： Avicularin; (2-Hydroxypropyl)-p-cyclodextrin; Molecular docking; Antioxidant ability

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）

ISSN： 2212-4292

年卷期： 2025 年 66 卷

页码：

收录情况： SCI

摘要： Avicularin, commonly found in apples and mangos, possessed various health-promoting effects. However, the application of avicularin in functional foods was hindered by its limited water solubility and chemical instability. A freeze-drying-based technique was employed to formulate a complex using avicularin and (2-hydroxypropyl)p-cyclodextrin (HP-p-CD) to improve these properties. The synthesis and structure of the complex were featured by changes in fourier transform infrared spectroscopy (FT-IR), the phase transition recorded by differential scanning calorimetry (DSC), the changes in crystal structures provided by X-ray diffractometry (XRD), the visualized changes in surface morphology determined by scanning electron microscopy (SEM). Additionally, proton nuclear magnetic resonance spectroscopy (1H NMR) analysis and molecular docking simulations demonstrated the A ring of avicularin entered into the cavity of HP-p-CD to form a supramolecular complex. The complex of avicularin resulted in its increased water solubility (22 times), and enhanced chemical stability against heat and alkaline conditions, especially at pH 9,10, with an improvement of up to 50%. Meanwhile, the inclusion complex improved antioxidant activity in the cellular assays, especially at 120 mu g/mL, with an improvement of up to 35%. This work provided a solid basis for potential applications of avicularin in functional foods and nutraceuticals.

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