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A highly Swellable hydrogel encapsulating Ginsenoside Rh4 for obesity regulation

文献类型： 外文期刊

作者： Liu, Yanan 1 ; Yang, Haixia 3 ; Fan, Daidi 1 ; Deng, Jianjun 1 ;

作者机构： 1.Northwest Univ, Sch Chem Engn, Shaanxi R&D Ctr Biomat Fermentat Engn, Shaanxi Key Lab Degradable Biomed Mat,Biotech & Bi, Xian 710069, Peoples R China

2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, State Key Lab Vegetable Biobreeding, Beijing 100081, Peoples R China

3.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China

关键词： Highly swellable; Obesity management; Hydrogel; Ginsenoside Rh4

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.0； 五年影响因子：8.5 ）

ISSN： 0963-9969

年卷期： 2025 年 218 卷

页码：

收录情况： SCI

摘要： In the management of obesity, dietary intervention has become an effective approach due to its biosafety. Edible hydrogels, fabricated from natural polysaccharides and proteins, have emerged as promising alternatives for weight control. In this study, a highly swellable hydrogel encapsulating hypoglycemic and anti-inflammatory ginsenoside Rh4 was developed to regulate obesity, which integrated by natural-derivated carboxymethyl cellulose (CMC) and whey protein (WPI). The physical and chemical characterization results demonstrated the excellent mechanical properties and high swelling ratio of the designed hydrogel. The in vitro and in vivo results suggest that the hydrogel with optimized formulation exhibits significant drug sustained releasing, superior biocompatibility, as well as obesity-induced inflammation alleviation and intestinal flora regulation. Taken together, this edible hydrogel has the advantages for convenient preparation and reliable stability, conferring it with a great potential for the clinical obesity regulation.

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