Combination of Ginsenoside Compound K and Anti-PD1 Inhibits Pancreatic Cancer by Activating CXCL13-CXCR5 Signaling Axis
文献类型： 外文期刊
作者： Shang, Shiyan 1 ; Yang, Haixia 3 ; Fan, Daidi 1 ; Deng, Jianjun 1 ;
作者机构： 1.Northwest Univ, Biotech & Biomed Res Inst, Shaanxi R&D Ctr Biomat & Fermentat Engn, Sch Chem Engn,Shaanxi Key Lab Degradable Biomed Ma, Xian 710069, Peoples R China
2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, State Key Lab Vegetable Biobreeding, Beijing 100081, Peoples R China
3.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
关键词： ginsenosideCK; anti-PD1; pancreatic cancer; combinationtherapy
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）
ISSN： 0021-8561
年卷期： 2025 年 73 卷 24 期
页码：
收录情况： SCI
摘要： Pancreatic cancer is a highly malignant tumor with a poor prognosis, making it a leading cause of cancer-related deaths. While immune checkpoint inhibitors (ICIs) have shown efficacy in treating various solid tumors, their effectiveness in pancreatic cancer is limited due to its unique tumor immune microenvironment (TIME). Thus, developing novel combination therapies is critical. Ginsenoside compound K (CK), a natural product with antitumor and immunomodulatory properties, holds the potential for combination therapy with ICIs. This study investigates the therapeutic effects of CK combined with Anti-PD1 inhibitors in a Panc02 tumor model. The combination therapy significantly improved survival, enhanced T-cell infiltration and activation, remodeled the tumor stroma by reducing collagen I and alpha-SMA, and improved vasculature formation. RNA sequencing revealed changes in genes associated with T-cell activation, chemokines, and angiogenesis. These findings suggest that CK combined with Anti-PD1 therapy offers a promising strategy for pancreatic cancer treatment by modulating TIME and enhancing antitumor activity.
- 相关文献
作者其他论文 更多>>
-
Dietary Triterpenoids in Functional Food and Drug Ingredients: A review of structure-activity relationships, biosynthesis, applications, and AI-driven strategies
作者：Fang, Chao;Fan, Daidi;Yang, Haixia;Deng, Jianjun;Deng, Jianjun
关键词：Triterpenoids; Structure-activity relationships; Biosynthesis; Bioactivity; Applications; AI-Assisted strategies
-
Effects of drying methods on phytochemicals and antioxidant activity of broccoli by-products
作者：Zhao, Yaqi;Zhang, Wenyuan;Zhang, Zhanquan;Deng, Jianjun;Yang, Haixia;Xu, Zhenzhen;Wang, Xue
关键词：Broccoli by-products; Drying methods; Phytochemical composition; Antioxidant capacity
-
Hydrogels for Long-Term Moisture Retention under Ambient Conditions: Inhibiting the Evaporation of Free Water from Macroscopic to Molecular Scales
作者：Liu, Yong;Shen, Shihong;Duan, Zhiguang;Deng, Jianjun;Fan, Daidi;Deng, Jianjun
关键词：anti-dehydration; hygroscopicity; moisturizing hydrogel; multi-scale; water state
-
Characterization of differences in volatile compounds and metabolites of six varieties of potato with different processing properties
作者：Zhang, Wenyuan;Li, Liang;Zhao, Yaqi;Zhang, Xuejie;Zhang, Zhanquan;Wang, Wanxing;Deng, Jianjun;Yang, Haixia;Wang, Xue;Xu, Zhenzhen
关键词：Potato; Fresh eating; Food processing; Volatile compound; Metabolites
-
Ginsenoside, a potential natural product against liver diseases: a comprehensive review from molecular mechanisms to application
作者：Shang, Shiyan;Qu, Linlin;Fan, Daidi;Deng, Jianjun;Yang, Haixia;Deng, Jianjun
关键词：Ginsenosides; hepatopathy; mechanisms; applications
-
Advances in Nanotechnology Research in Food Production, Nutrition, and Health
作者：Han, Kangran;Fan, Daidi;Deng, Jianjun;Yang, Haixia;Deng, Jianjun
关键词：nanotechnology; food production; nutritional delivery; human health; safety
-
A highly Swellable hydrogel encapsulating Ginsenoside Rh4 for obesity regulation
作者：Liu, Yanan;Fan, Daidi;Deng, Jianjun;Deng, Jianjun;Yang, Haixia
关键词：Highly swellable; Obesity management; Hydrogel; Ginsenoside Rh4
