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Synthesis and Fungicidal Activities of Nucleoside Compounds Containing Substituted Benzoyl Thiourea

文献类型: 外文期刊

作者: Miao Hongjian 1 ; Zhang Jiwei 1 ; Yuan Huizhu 2 ; Li Ying 1 ; Xu Yan 1 ; Li Hui 1 ; Yang Xinling 1 ; Ling Yun 1 ;

作者机构: 1.China Agr Univ, Dept Appl Chem, Coll Sci, Key Lab Pesticide Chem & Applicat,Minist Agr, Beijing 100193, Peoples R China

2.Chinese Acad Agr Sci, Inst Plant Protect, Beijing 100193, Peoples R China

关键词: chitin;polyoxins;uridine;thiourea;fungicidal activity

期刊名称:CHINESE JOURNAL OF ORGANIC CHEMISTRY ( 影响因子:1.652; 五年影响因子:1.2 )

ISSN: 0253-2786

年卷期: 2012 年 32 卷 5 期

页码:

收录情况: SCI

摘要: To find new fungicidal lead compounds, based on the catalytic mechanism of chitin synthase, a series of novel nucleoside compounds containing thiourea were designed via the method of linking active sub-structures, in which the thiourea with high fungicidal activity was combined to the uridine part of polyoxins and nikkomycins. The target compounds were synthesized from uridine in 5 steps. Their structures were confirmed by IR, H-1 NMR spectra and elemental analysis. The preliminary bioassay results indicated that some compounds showed obvious inhibition effects against Phomopsisasparagi bubak, especially, and the fungicidal activity of 6m (97.2%) at 50 mu g/mL is similar to that (100%) of polyoxin B.

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