Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro
文献类型： 外文期刊
作者： Cui, Zhanding 1 ; Liu, Jinlong 2 ; Wang, Jinlong 2 ; Zhang, Jing 2 ; Cao, Yimei 2 ; Li, Kun 2 ; Zhao, Zhixun 2 ; Yuan, Hong 2 ; Bai, Xingwen 2 ; Ma, Xueqing 2 ; Li, Pinghua 2 ; Fu, Yuanfang 2 ; Bao, Huifang 2 ; Li, Dong 2 ; Zhang, Qiang 2 ; Liu, Zaixin 2 ; Li, Kai 1 ; Xu, Tong 1 ; Lu, Zengjun 2 ;
作者机构： 1.Hebei North Univ, Anim Sci Coll, Dept Vet Med, Key Lab Prevent Vet Med, Zhangjiakou 075000, Hebei, Peoples R China
2.Chinese Acad Agr Sci, Lanzhou Univ,Lanzhou Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Coll Vet Med, Lanzhou, Peoples R China
3.Gansu Agr Univ, Inst Tradit Chinese Vet Med, Coll Vet Med, Lanzhou, Peoples R China
关键词： Porcine Reproductive and Respiratory Syndrome; formononetin; antiviral agent; mizoribine; swine viral infections
期刊名称：FRONTIERS IN NUTRITION （ 影响因子：5.1； 五年影响因子：5.4 ）
ISSN： 2296-861X
年卷期： 2025 年 11 卷
页码：
收录情况： SCI
摘要： This study delves into the antiviral efficacy of Formononetin (FMN) and Mizoribine (MZR) against the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a virus with a considerable economic impact and a current void in effective treatments. FMN and MZR were found to inhibit various PRRSV strains in vitro, predominantly in the early stages of viral infection. Noteworthy was the observation of their synergistic effects when combined with Ribavirin. The study underscores the antiviral potential of FMN and MZR, particularly emphasizing their low cytotoxicity at specific concentrations. These results position FMN and MZR as promising antiviral agents against PRRSV, underscoring their low cytotoxicity and efficacy in early-stage viral inhibition. Such findings pave the way for their potential inclusion in future PRRSV management strategies.
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