您好,欢迎访问中国农业科学院 机构知识库!

SFRP2 affects prenatal muscle development and is regulated by microRNA-1/206 in pigs

文献类型: 外文期刊

作者: Ma Yan-jiao 1 ; Yang Ya-lan 2 ; Sun Wei 3 ; Zhou Rong 2 ; Li Kui 2 ; Tang Zhong-lin 2 ;

作者机构: 1.Jilin Univ, Coll Anim Sci, Jilin Prov Key Lab, Changchun 130012, Peoples R China

2.Chinese Acad Agr Sci, Key Lab Farm Anim Genet Resources & Germplasm Inn, Minist Agr, Inst Anim Sci, Beijing 100193, Peoples R China

3.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Peoples R China

关键词: SFRP2;miRNA-206;miRNA-1;skeletal muscle;development;pig

期刊名称:JOURNAL OF INTEGRATIVE AGRICULTURE ( 影响因子:2.848; 五年影响因子:2.979 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Secreted frizzled-related protein 2 (SFRP2), a member of the SFRPs family, is associated with cell growth and differentiation in myogenesis. Our previous study suggested that SFRP2 was a potential target of microRNA (miRNA)-1/206, which was considered as myomiRs. To further explore the biological function and regulation mechanisms of the SFRP2 gene in porcine skeletal muscle development, we first analyzed the sequence structure of the porcine SFRP2 gene. Subsequently, we detected its tissue distribution in adult Tongcheng pigs (a Chinese indigenous breed) and investigated its dynamic expression in developmental skeletal muscle (13 prenatal and 7 postnatal time points) in Tongcheng pigs. An interaction analysis between SFRP2 and myomiRs was also performed. The results showed that the expression pattern of the SFRP2 varied greatly across diverse tissues. It exhibited abundant expression in prenatal skeletal muscle and peaked at 55 days post coitus (E55), and had a lower expression in postnatal skeletal muscle, indicating that the SFRP2 gene might affect porcine embryonic skeletal muscle development. Co-expression analysis revealed that the expression levels of SFRP2 correlated negatively with miRNA-1 (r=-0.570, P-value=0.009) and miRNA-206 (r=-0.546, P-value=0.013), but positively with SFRP1 (r=0.613, P-value=0.004). The bioinformatics analysis and dual luciferase assay verified that the SFRP2 was a putative target of rniRNA-1/206 in pigs. Therefore, this study is helpful for understanding the biological function and molecular regulation of the SFRP2 gene during porcine skeletal muscle development.

  • 相关文献

[1]Wnt antagonist, secreted frizzled-related protein 1, is involved in prenatal skeletal muscle development and is a target of miRNA-1/206 in pigs. Yang, Yalan,Sun, Wei,Wang, Ruiqi,Zhou, Rong,Tang, Zhonglin,Li, Kui,Yang, Yalan,Tang, Zhonglin,Li, Kui,Sun, Wei,Lei, Chuzhao. 2015

[2]CNN3 is regulated by microrna-1 during muscle development in pigs. Tang, Zhonglin,Liang, Ruyi,Zhao, Shuanping,Wang, Ruiqi,Li, Kui,Liang, Ruyi,Huang, Ruihua.

[3]OLFML3 expression is decreased during prenatal muscle development and regulated by microRNA-155 in pigs. Zhao, Shuanping,Zhang, Jing,Hou, Xinhua,Tang, Zhonglin,Li, Kui,Zhao, Shuanping,Zhang, Jing,Hou, Xinhua,Tang, Zhonglin,Li, Kui,Zan, Linsen,Wang, Ning.

[4]Identifying suitable reference genes for gene expression analysis in developing skeletal muscle in pigs. Niu, Guanglin,Yang, Yalan,Zhang, YuanYuan,Hua, Chaoju,Wang, Zishuai,Tang, Zhonglin,Li, Kui,Niu, Guanglin,Yang, Yalan,Tang, Zhonglin,Li, Kui. 2016

[5]Expression of the insulin-like growth factor system in skeletal muscle during embryonic and postnatal development in the first filial generation pigs from Erhualian and Yorkshire reciprocal crosses. Wang, Lijuan,Lin, Fei,Jiang, Baochun,Dong, Fulu,Liu, Honglin,Zhang, Guangmin. 2011

[6]Molecular characterization and expression analysis of the porcine caveolin-3 gene. Zhu, Zhengmao,Li, Yong,Mo, Delin,Li, Kui,Zhao, Shuhong.

[7]Genome-wide profiling of Sus scrofa circular RNAs across nine organs and three developmental stages. Liang, Guoming,Yang, Yalan,Niu, Guanglin,Tang, Zhonglin,Li, Kui,Liang, Guoming,Yang, Yalan,Tang, Zhonglin,Li, Kui,Liang, Guoming,Yang, Yalan,Tang, Zhonglin.

[8]Effects of Carbon Concentrations and Carbon to Nitrogen ratios on Sporulation of Two Biological Control Fungi as Determined by Different Culture Methods. Liu, Xingzhong,Gao, Li.

[9]Activation of mammalian target of rapamycin signaling in skeletal muscle of neonatal chicks: Effects of dietary leucine and age. Deng, Huiling,Zheng, Aijuan,Liu, Guohua,Chang, Wenhuan,Zhang, Shu,Cai, Huiyi. 2014

[10]Loss-of-function myostatin mutation increases insulin sensitivity and browning of white fat in Meishan pigs. Cai, Chunbo,Qian, Lili,Jiang, Shengwang,Wang, Qingqing,Ma, Dezun,Xiao, Gaojun,Li, Biao,Xie, Shanshan,Gao, Ting,Cui, Wentao,Li, Kui,Cai, Chunbo,Qian, Lili,An, Xiaorong,Gao, Ting,Chen, Yaoxing,Sun, Youde,Liu, Jie. 2017

[11]Comparison of muscle characteristics and underpinning mechanisms between Texel and Ujumqin sheep aged from day 70 to 135 of gestation. Li, Li,Wang, Linjie,Zhong, Tao,Zhang, Hongping,Su, Hongwei,Liu, Wenzhong,Wei, Caihong,Xu, Lingyang,Zhao, Fuping,Zhang, Li,Du, Lixin,Ren, Hangxing.

[12]Porcine skeletal muscle differentially expressed gene CMYA1: isolation, characterization, mapping, expression and association analysis with carcass traits. Xu, X. L.,Xu, X. W.,Pan, P. W.,Yu, M.,Liu, B.,Xu, X. L.,Xu, X. W.,Pan, P. W.,Yu, M.,Liu, B.,Li, K.,Jiang, Z. H.,Rothschild, M. F.,Rothschild, M. F..

[13]Identification and characterization of genes related to the development of breast muscles in Pekin duck. Xu, Tieshan,Huang, Wei,Hou, Shuisheng,Xu, Tieshan,Zhou, Hanlin,Zhang, Xiaohui,Ye, Baoguo.

[14]Differentiation of expression profiles of two calcineurin subunit genes in chicken skeletal muscles during early postnatal growth depending on anatomical location of muscles and breed. Shan Yan-ju,Xu Wen-juan,Shu Jing-ting,Zhang Ming,Song Wei-tao,Tao Zhi-yun,Zhu Chun-hong,Li Hui-fang. 2016

[15]A long-term high-fat, high-sucrose diet in Barna minipigs promotes lipid deposition and amyotrophy by up-regulating the myostatin pathway. Ruan, Jinxue,Yuan, Jing,Xin, Leilei,Xia, Jihan,Liu, Nan,Mu, Yulian,Yang, Shulin,Li, Kui,Ruan, Jinxue,Zhang, Yuanyuan,Chen, Yaoxing,Yuan, Jing,Liu, Nan,Li, Kui. 2016

[16]Expression Characters of IGF2 and IGFBP3 in Eight Tissues of Wuzhishan Pig. Hou Guanyu,Wang Dongjin,Zhou Hanlin,Zeng Hongpu,Guan Song,Ma Yuehui. 2011

[17]Expression patterns of peroxisome proliferator-activated receptor gamma 1 versus gamma 2, and their association with intramuscular fat in goat tissues. Li, Li,Jiang, Jing,Wang, LinJie,Zhong, Tao,Chen, Bo,Zhan, Siyuan,Zhang, Hongping,Li, Li,Du, Lixin.

[18]Role of the ubiquitin-proteasome pathway on proteolytic activity in postmortem proteolysis and tenderisation of sheep skeletal muscle. Liu, Yue,Du, Manting,Li, Xin,Chen, Li,Zhang, Dequan,Liu, Yue,Tian, Jianwen,Shen, Qingwu.

[19]Development And Biomechanical Evaluation Of An Injectable Radiopaque Polypropylene Fumarate Bone Cement For Kyphoplasty. A. Perry,A. Mahar,J. Massie,L. Lu,M. J. Yaszemski,S. R. Garfin,C. W. Kim. 2005

[20]Effect of Natural Phenolics on the Thermal and Processing Behaviour of Poly(3-Hydroxybutyrate). Maria Auriemma,Amodio Piscitelli,Rossana Pasquino,Pierfrancesco Cerruti,Stefania Angelini,Gennaro Scarinzi,Mario Malinconico,Nino Grizzuti. 2015

作者其他论文 更多>>